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TranscriptomicsWhole genome gene expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells
HTLV-1 infected individuals stay as carriers for their lifetimes, while the rest of 5% are killed by ATL. ATL leukemogenesis is a complex process involving accumulation of multiple genetic abnormalities in HTLV-1 infected cells. To clarify genetic events underlying ATL leukemogenesis, we conducted c...
ORGANISM(S): Homo sapiens 
2012-02-23 | E-GEOD-33615 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of FoxP3-expressing or non-expressing subsets of human CD4+ T cells
Gene expression profiles of subsets of CD4+ T cells according to their expression of FoxP3 and CD45RA were compared. Abstract: FoxP3 is a key transcription factor for the development and function of natural CD4+ regulatory T cells (Tregs). Here we show that human FoxP3+CD4+ T cells are composed of...
ORGANISM(S): Homo sapiens 
2009-05-21 | E-GEOD-15659 | biostudies-arrayexpress
TranscriptomicsmiRNA expression profiling in Adult T-cell Leukemia (ATL) cells and in Normal CD4+ T-cells
HTLV-1 infected individuals stay as carriers for their lifetimes, while the rest of 5% are killed by ATL. ATL leukemogenesis is a complex process involving accumulation of multiple genetic abnormalities in HTLV-1 infected cells. To clarify genetic events underlying ATL leukemogenesis, we conducted c...
ORGANISM(S): Homo sapiens 
2012-02-23 | E-GEOD-31629 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for acute T-cell leukemia/lymphoma (ATL)
SNP array analysis was performed using 168 ATL specimens. To obtain genotypes and intensities for each SNP, Affymetrix 250K SNP arrays were performed for 168 ATL samples.
ORGANISM(S): Homo sapiens 
2012-02-23 | E-GEOD-33602 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse SKG FR4-CD4+ cells and age-matched BALB/c FR4-CD4+ cells, and between IFN-g-/- CD4+ cells transferred to RAG2-/- mice and IL-6-/- CD4+ T cells transferred to IL-6-/- RAG2-/- mice
Th17 cells are enriched by sorting FR4-CD4+ T cells from SKG mice. A large number of Th17 cells also develop spontaneously when CD4+ T cells from IFN-g-deficient (IFN-g-/-) BALB/c mice are transferred to T cell-deficient RAG2-deficient (RAG2-/-) mice and subjected to homeostatic proliferation, where...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9316 | biostudies-arrayexpress
UnknownIntratumoural-infiltrating CD4 + and FOXP3 + T cells as strong positive predictive markers for the prognosis of resectable colorectal cancer.
Not available
S-EPMC6889292 | biostudies-literature
UnknownImproved survival of chimeric antigen receptor-engineered T (CAR-T) and tumor-specific T cells caused by anti-programmed cell death protein 1 single-chain variable fragment-producing CAR-T cells.
Not available
S-EPMC6778656 | biostudies-literature
ProteomicsArabidopsis cell LC-MSMS - Proteomics analysis reveals a highly heterogeneous proteasome composition and the post-translational regulation of peptidase activity under pathogen signaling in plants
26S proteasome was affinity-purified with anti-FLAG beads and separated by 2-DE method. Each spot was cut and digested by Trypsin enzyme, which finaly applied for LC-MS/MS nalysis using a LTQ-Orbitrap XL (Thermo Scientific). The obtained spectra were compared against 35,386 sequences in The Arabidop...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2014-07-28 | PXD000417 | Pride
26sp 
UnknownTheoretical modeling reveals that regulatory T cells increase T-cell interaction with antigen-presenting cells for stable immune tolerance.
Not available
S-EPMC6794947 | biostudies-literature
UnknownHomeostatic Expansion of CD4+ T Cells Promotes Cortical and Trabecular Bone Loss, Whereas CD8+ T Cells Induce Trabecular Bone Loss Only.
Not available
S-EPMC5853557 | biostudies-literature
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