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TranscriptomicsDistinct STAT5 concentrations uniquely control establishment and differentiation of mammary epithelium during pregnancy
To dissect regulatory processes of cell proliferation and differentiation we generated mouse strains carrying any combination of the four Stat5 alleles, thus expressing STAT5 from 0 to 100%. RNA-Seq analyses revealed that different STAT5 levels activate specific genetic programs linked to cell proli...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-37646 | biostudies-arrayexpress
GenomicsImpact of STAT5 dosage and binding location on genetic and biological programs activated in mouse mammary epithelium during pregnancy.
The transcription factor STAT5 has long been recognized as an important mediator of prolactin induced mammary development during pregnancy. We have used mouse genetics and genome-wide analyses to determine how altering concentrations of STAT5A and STAT5B impacts different target promoters. Examinati...
ORGANISM(S): Mus musculus 
2012-09-18 | E-GEOD-40930 | biostudies-arrayexpress
TranscriptomicsDevelopment of mammary luminal progenitor cells is controlled by the transcription factor STAT5A
Mammary alveologenesis is abrogated in the absence of the transcription factors STAT5A/5B that mediate cytokine signaling. To reveal the underlying causes for this developmental block we studied mammary stem and progenitor cells. While loss of STAT5A/5B did not affect the stem cell population and ...
ORGANISM(S): Mus musculus 
2009-10-21 | E-GEOD-17723 | biostudies-arrayexpress
GenomicsMammary-specific gene activation is defined by progressive recruitment of STAT5 followed by the establishment of H3K4me3 marks
STAT5A and H3K4me3 ChIP-seq with wild-type mammary gland tissues (day 6 of pregnancy). Examination of genome-wide STAT5A and H3K4me3 in wild type mammary tissues.
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-48685 | biostudies-arrayexpress
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