Sort   by:  
 Page size 
UnknownLooping probabilities in model interphase chromosomes.
Fluorescence in-situ hybridization (FISH) and chromosome conformation capture (3C) are two powerful techniques for investigating the three-dimensional organization of the genome in interphase nuclei. The use of these techniques provides complementary information on average spatial distances (FISH) a...
S-EPMC2877331 | biostudies-literature
UnknownDelivery of the reduced form of vitamin K2(20) to NIH/3T3 cells partially protects against rotenone induced cell death.
Mitochondria generate energy through the action of the electron transport chain (ETC) and ATP synthase. Mitochondrial malfunction can lead to various disorders, including neurodegenerative diseases. Several reports have shown that menaquinone-4 (MK-4, vitamin K2(20)), a safe drug for oste...
S-EPMC9674836 | biostudies-literature
UnknownAntitumor Effects and Delivery Profiles of Menahydroquinone-4 Prodrugs with Ionic or Nonionic Promoiety to Hepatocellular Carcinoma Cells.
Hepatocellular carcinoma (HCC) shows poor prognosis owing to its very frequent recurrence even after curative treatment. Thus, an effective and safe long-term chemopreventive agent is strongly in demand. Menahydroquinone-4 (MKH) is an active form of menaquinone-4 (MK-4, vitamin K₂) that is involved ...
S-EPMC6100056 | biostudies-literature
UnknownIsolation, cDNA cloning, and structure-based functional characterization of oryctin, a hemolymph protein from the coconut rhinoceros beetle, Oryctes rhinoceros, as a novel serine protease inhibitor.
We isolated oryctin, a 66-residue peptide, from the hemolymph of the coconut rhinoceros beetle Oryctes rhinoceros and cloned its cDNA. Oryctin is dissimilar to any other known peptides in amino acid sequence, and its function has been unknown. To reveal that function, we determined the solution stru...
S-EPMC2943256 | biostudies-literature
UnknownMenahydroquinone-4 may play a key role in regulating CCL5 expression induced by epidermal growth factor receptor inhibitors.
Epidermal growth factor receptor (EGFR) inhibitors frequently cause severe skin rash as a side effect, which is a critical burden for patients who continuously receive drug treatments. Several recent clinical trials have shown that vitamin K is effective against these side effects; however, the unde...
S-EPMC10719312 | biostudies-literature
UnknownEfficacy and safety of esaxerenone (CS-3150) for the treatment of essential hypertension: a phase 2 randomized, placebo-controlled, double-blind study.
This was a phase 2, multicenter, randomized, double-blind, placebo-controlled, open-label comparator study to investigate the efficacy and safety of esaxerenone (CS-3150), a novel non-steroidal mineralocorticoid receptor blocker, in Japanese patients with essential hypertension. Eligible patients (n...
S-EPMC6760614 | biostudies-literature
UnknownL-asparaginase Production by Leucosporidium scottii in a Bench-Scale Bioreactor With Co-production of Lipids.
L-asparaginase (ASNase) is a therapeutical enzyme used for treatment of acute lymphoblastic leukemia. ASNase products available in the market are produced by bacteria and usually present allergic response and important toxicity effects to the patients. Production of ASNase by yeasts could be an alte...
S-EPMC7773903 | biostudies-literature
UnknownOrigin of switchable quasiparticle-interference chirality in loop-current phase of kagome metals measured by scanning-tunneling-microscopy.
In the kagome superconductors AV3Sb5 (A=Cs,Rb,K), a cascade of correlated electron phases cause exotic symmetry-breaking quantum states. In particular, the dissipationless chiral loop-current phase has been attracting increasing attention. A crucial clue is offered by the chira...
S-EPMC12572650 | biostudies-literature
UnknownNutritional Status and Oral Frailty: A Community Based Study.
Compromised oral health can alter food choices. Poor masticatory function leads to imbalanced food intake and undesirable nutritional status. The associations among nutritional status, oral health behavior, and self-assessed oral functions status were investigated using a community-based survey. In ...
S-EPMC7551233 | biostudies-literature
UnknownA2B adenosine receptor inhibition by the dihydropyridine calcium channel blocker nifedipine involves colonic fluid secretion.
The adenosine A2B receptor is a critical protein in intestinal water secretion. In the present study, we screened compound libraries to identify inhibitors of the A2B receptor and evaluated their effect on adenosine-induced intestinal fluid secretion. The screening identified t...
S-EPMC7044278 | biostudies-literature
Sort   by:  
 Page size