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UnknownEpigenetic alteration to activate Bmp2-Smad signaling in Raf-induced senescence.
Not available
S-EPMC4768123 | biostudies-literature
TranscriptomicsHCT 116 cells expressing Fucci (fluorescent ubiquitination-based cell cycle indicator); G1 phase vs. S/G2/M phase
Fucci-expressing HCT116 were inoculated into subcutaneous tissue or cecum of NOD/SCID mice. Four weeks after inoculation, Fucci green (mAG; S/G2/M) and red (mKO2;G1) expressing cells were isolated from implanted tumors by FACSAria sorting (BD, Biosciences). Comparative analyses among green and red c...
ORGANISM(S): Homo sapiens 
2014-01-09 | E-GEOD-34940 | biostudies-arrayexpress
TranscriptomicsEpigenetic regulation of Bmp2 and Smad6 in Ras-induced senescence
Epigenetically silenced Ink4a-Arf locus is activated by loss of H3K27me3 in cellular senescence, where secreted factor expression is also involved. Here we analyzed epigenome and transcriptome alteration during Ras-induced senescence using mouse embryonic fibroblast (MEF). Seventeen genes with H3K27...
ORGANISM(S): Mus musculus 
2011-12-22 | E-GEOD-18125 | biostudies-arrayexpress
ProteomicsProtein expression in pancreatic cancer cell lines and normal pancreatic ductal cell line.
Pancreatic cancer (PC) is the sixth leading cause of cancer-associated death worldwide. Despite improvements in treatment methods, the 5-year survival rate of PC patients is still low. Although carbohydrate antigen (CA) 19-9 has been used as the most specific and sensitive biomarker for the diagnosi...
ORGANISM(S): Homo Sapiens (human) 
2025-12-03 | PXD061294 | JPOST Repository
TranscriptomicsExpression data from various tomato plant tissues
Gene-to-gene coexpression analysis is a powerful approach to infer function of uncharacterized genes. To perform non-targeted coexpression analysis of tomato genes, we collected a developmental gene expression dataset using various tissues of tomato plant. Expression data are collected from 24 diffe...
ORGANISM(S): Solanum lycopersicum 
2010-02-21 | E-GEOD-19326 | biostudies-arrayexpress
TranscriptomicsGSTP1 expression predicts poor pathological complete response to neoadjuvant chemotherapy in ER-negative breast cancer
The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers. The relationship of GSTP1 expression and GSTP1 prom...
ORGANISM(S): Homo sapiens 
2012-03-20 | E-GEOD-32646 | biostudies-arrayexpress
TranscriptomicsGene repression with H3K27me3 modification in human small cell lung cancer
Small cell lung cancer (SCLC) is a subtype of lung cancer with poor prognosis due to early dissemination and rapid growth. We here analyze gene expression profile of 23 clinical SCLC samples. EZH2 was found to be highly expressed in SCLC samples compared to 42 normal tissues including the normal lun...
ORGANISM(S): Homo sapiens 
2013-06-12 | E-GEOD-43346 | biostudies-arrayexpress
ProteomicsProtein expression in heated rat lens using shotgun proteomics
Previous studies have reported that a strong correlation between the estimated cumulative thermal exposure in the crystalline lens and the incidence of nuclear cataracts; however, the precise relationship between temperature and cataracts remains to be fully elucidated. In the present study, the sho...
ORGANISM(S): Rattus 
2024-09-22 | PXD056067 | JPOST Repository
TranscriptomicsAberrant DNA methylation in hepatitis B and C virus-related hepatocellular carcinoma
Chronic infections by hepatitis B virus (HBV) and hepatitis C virus (HCV) appear to be the most significant causes of hepatocellular carcinoma (HCC). Aberrant promoter methylation is known to be deeply involved in cancer, including HCC. In this study, we analyzed aberrant promoter methylation on gen...
ORGANISM(S): Homo sapiens 
2010-07-06 | E-GEOD-19665 | biostudies-arrayexpress
MetabolomicsMetabolite profiling of the fermentation process of yamahai-ginjo-shikomi Japanese sake
Sake is a traditional Japanese alcoholic beverage prepared by multiple parallel fermentation of rice. The fermentation process of yamahai-ginjo-shikomi sake is mainly performed by three microbes, Aspergillus oryzae, Saccharomyces cerevisiae, and Lactobacilli; the levels of various metabolites fluctu...
2018-06-29 | MTBLS451 | MetaboLights
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