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TranscriptomicsComparison of expression profiles of WT and Nrf2AY/AY mutant macrophages under electrophilic stress agent
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-75177 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of anaplastic glioma with or without the mutated IDH1/2 gene
To examine the NRF2 activity in anaplastic glioma with mutated IDH1/2, we conducted the microarray analysis to measure the expression levels of representative NRF2 target genes, including NQO1, HMOX1, GCLM, TXNRD1, and PRDX1. 12 anaplastic gliomas with or without mutated IDH1/2.
ORGANISM(S): Homo sapiens 
2013-12-04 | E-GEOD-52942 | biostudies-arrayexpress
TranscriptomicssiRNA profiling of human HUVEC cells after WTAP knockdown
The experiment studied the effect of knockdown WTAP in HUVEC. two control samples and two WTAP knockdown samples.
ORGANISM(S): Homo sapiens 
2008-06-12 | E-GEOD-2327 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles of MafF-/-: MafG-/-: MafK-/- embryos and MafF-/-: MafG+/+: MafK-/- embyos
MafF-/-: MafG+/+: MafK-/- mice are viable, while MafF-/-: MafG-/-: MafK-/- mice are embryonic lethal. To get an insight into the cause of the lethality of small Maf triple knockout mice, transcriptome analysis was performed using whole embyos of MafF-/-: MafG-/-: MafK-/- at E10.5 and those of MafF-...
ORGANISM(S): Mus musculus 
2012-01-09 | E-GEOD-29558 | biostudies-arrayexpress
TranscriptomicsMouse primary megakaryocytes, wild type & NF-E2p45-deficient
To identify p45 target genes, we conducted gene expression profiling with p45-null megakaryocytes cultured from E14.5 fetal liver. Many genes encoding membrane proteins and enzymes related to platelet function, including Txas, Glycoprotein 6 (Gp6) and Selectin P (Selp), were repressed in the absence...
ORGANISM(S): Mus musculus 
2010-03-22 | E-GEOD-15581 | biostudies-arrayexpress
GenomicsNrf2 bindng in C2C12 myotubes
Nrf2 (NF-E2-related-factor-2) contributes to the maintenance of glucose homeostasis in vivo. Nrf2 suppresses blood glucose levels by protecting pancreatic β-cells from oxidative stress and improving peripheral tissue glucose utilization. To elucidate the molecular mechanisms by which Nrf2 contribut...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-78780 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles among Nrf1 liver-specific conditional knockout, Nrf2 knockout and Keap1 knockdown mice.
To identify Nrf1-dependent and Nrf2-dependent genes in the liver, we examined the gene expression profiles of Nrf1 Alb-CKO, Nrf2 knockout and Keap1 knockdown mouse livers by microarray analyses. Total RNAs from Nrf1dN/-::Alb-Cre, Nrf1dN/+, Nrf2-/-, Nrf2+/+, Keap1KD/- and Keap1KD/+ mouse livers were ...
ORGANISM(S): Mus musculus 
2012-05-17 | E-GEOD-35124 | biostudies-arrayexpress
GenomicsComparison of expression profiles of WT and Nrf2AY/AY mutant macrophages under electrophilic stress agent [ChIP-Seq]
Nrf2(A502Y) mutant macrophages Nrf2(AY/AY) macrophages were more susceptible to toxicity of xenobiotics. To confirm preferences of binding sequences of Nrf2 and Nrf2A502Y in vivo, we performed ChIP-Seq analyses using an anti-Nrf2 antibody on the DEM-treated peritoneal macrophages derived from Nrf2+/...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-75175 | biostudies-arrayexpress
TranscriptomicsExpression data in Hepa1c1c7 cells treated with Nrf2 activator, diethyl maleate (DEM)
To examine the gene expression profile of Hepa1c1c7 cells in response to DEM, we performed microarray analysis. Two independent RNA samples from Hepa1c1c7 cells (a mouse hepatoma cell line) treated with 100-µM DEM or DMSO for 6 hours were used for the microarray analysis.
ORGANISM(S): Mus musculus 
2012-10-03 | E-GEOD-38350 | biostudies-arrayexpress
TranscriptomicsExpression profile of cortices, hippocampi and brainstems of Nrf2 knockout mice under unstressed conditions
Microarray analysis of cortices, hippocampi and brainstems of Nrf2 knockout mice, Three independent RNAs from cortices, hippocampi and brainstems of Nrf2 knockout and wild-type control mice were used for the microarray analyses.
ORGANISM(S): Mus musculus 
2013-08-05 | E-GEOD-47587 | biostudies-arrayexpress
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