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TranscriptomicsExpression profiling of 36 types of normal human tissues to identify tissue-specific genes
We performed expression profiling of 36 types of normal human tissues and identified 2,503 tissue-specific genes. We then systematically studied the expression of these genes in cancers by re-analyzing a large collection of published DNA microarray datasets. Our study shows that integration of each ...
ORGANISM(S): Homo sapiens 
2005-04-03 | E-GEOD-2361 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human umbilicial vein endothelial cells after TNF-alpha treatment
The many steps involved in the production of a mature mammalian mRNA are extensively coupled, and levels of both precursors and products can be measured using expression and genomic tiling microarrays. Different probes in these arrays targeting the same transcript often give different signals; then...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-9055 | biostudies-arrayexpress
GenomicsGenome-wide maps of MEF2C and H3K27ac localization in HUVECs
MEF2C is one of the substantially expressed transcriptional factors in endothelial cells, but its genomic localization is unknown. This time, we established a new antibody for MEF2C, and performed ChIP-seq to identify MEF2C binding site in whole genome manner. H3K27Ac binding sites were also detec...
ORGANISM(S): Homo sapiens 
2013-01-01 | E-GEOD-32644 | biostudies-arrayexpress
TranscriptomicsExpression data of HUVEC cells after TNF-alpha treatment
Tumor necrosis factor a (TNF-aplha) is a potent cytokine that orchestrates the inflammatory response by sequentially activating the expression of many genes in cultured human umbilical vein cells (HUVECs). We apply samples collected every 7.5 min to arrays and monitor the growth of several long tran...
ORGANISM(S): Homo sapiens 
2007-09-19 | E-GEOD-9036 | biostudies-arrayexpress
TranscriptomicsHIF1 is a master regulator of the adaptive gene expression to hypoxia.
Total 23 samples were derived from [1] HUVEC treated in the absence (0h) or presence of hypoxia (1, 2, 4, 8, 12, and 24 hrs) to determine hypoxia-regulated gene in endothelial cells, [2] control siRNA or HIF1? siRNA transfected HUVEC cells treated in the absence or presence of hypoxia, [3] control s...
ORGANISM(S): Homo sapiens 
2012-06-06 | E-GEOD-35932 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of gastric cancer by oligonucleotide microarrays
To gain molecular understanding of carcinogenesis, progression, and diversity of gastric cancer, 22 primary human advanced gastric cancer tissues and 8 noncancerous gastric tissues were analyzed by high-density oligonucleotide microarray in this study. Based on expression analysis of approximately 6...
ORGANISM(S): Homo sapiens 
2005-05-22 | E-GEOD-2685 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for myelodysplastic syndromes (MDS) and related neoplasms
In this study, to obtain a complete registry of genetic lesions in MDS and to identify novel therapeutic targets, we performed SNP array analysis and whole exome analysis for novel mutations using high-throughput sequencing technologies. In whole exome analysis, paired CD3-positive T cells were used...
ORGANISM(S): Homo sapiens 
2011-09-11 | E-GEOD-31174 | biostudies-arrayexpress
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