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GenomicsGenome wide localization of CTCF in activated mouse B cells
Identify CTCF binding sites in activated mouse B cells. Single ChIP experiment
ORGANISM(S): Mus musculus 
2011-11-19 | E-GEOD-33819 | biostudies-arrayexpress
GenomicsGenome wide localization of Activation induced cytidine deaminase (AID), Spt5, and RNA Polymerase II (PolII) in mouse
Activation induced cytidine deaminase (AID) initiates antibody gene diversification by creating U:G mismatches. However, AID is not specific for antibody genes. Off-target lesions can activate oncogenes or cause chromosome translocations. Despite its importance in these key transactions little is kn...
ORGANISM(S): Mus musculus 
2010-10-05 | E-GEOD-24178 | biostudies-arrayexpress
GenomicsThe In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci
The critical initial step in V(D)J recombination, binding of RAG1 and RAG2 to recombination signal sequences flanking antigen receptor V, D, and J gene segments, has not previously been characterized in vivo. Here we demonstrate that RAG protein binding occurs in a highly focal manner to a small reg...
ORGANISM(S): Mus musculus 
2010-04-19 | E-GEOD-21207 | biostudies-arrayexpress
Genomicsc-Myc is a universal amplifier of gene expression
This SuperSeries is composed of the following subset Series: GSE37222: c-Myc is a universal amplifier of gene expression [Microarray] GSE37229: c-Myc is a universal amplifier of gene expression [ChIP-Seq] Refer to individual Series
ORGANISM(S): Mus musculus 
2012-09-27 | E-GEOD-37230 | biostudies-arrayexpress
Transcriptomicsc-Myc is a universal amplifier of gene expression [Microarray]
The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism and differentiation at the cellular, tissue or organismal levels via regulation of numerous target genes. In part due to the incomplete inventory and functional accounting of ...
ORGANISM(S): Mus musculus 
2012-09-27 | E-GEOD-37222 | biostudies-arrayexpress
Genomicsc-Myc is a universal amplifier of gene expression [ChIP-Seq]
The c-Myc HLH-bZIP protein has been implicated in physiological or pathological growth, proliferation, apoptosis, metabolism and differentiation at the cellular, tissue or organismal levels via regulation of numerous target genes. In part due to the incomplete inventory and functional accounting of ...
ORGANISM(S): Mus musculus 
2012-09-27 | E-GEOD-37229 | biostudies-arrayexpress
TranscriptomicsA mouse model of endemic Burkitt translocations reveals the long-range boundaries of Ig-mediated oncogene deregulation
Igh/Myc translocations underlie both sporadic Burkitt lymphoma (BL) and the endemic clinical form affecting African children infected with malaria. However, while sporadic translocations decapitate Myc from 5' proximal regulatory elements, most endemic events occur hundreds of kilobases away from My...
ORGANISM(S): Mus musculus 
2013-07-04 | E-GEOD-48514 | biostudies-arrayexpress
GenomicsRif1 Prevents Resection of DNA Breaks and Promotes Immunoglobulin Class Switching
DNA double-strand breaks (DSBs) represent a threat to the genome because they can lead to loss of genetic information and chromosome rearrangements. The DNA repair protein p53 binding protein 1 (53BP1) protects the genome by limiting nucleolytic processing of DSBs by a mechanism that requires its ph...
ORGANISM(S): Mus musculus 
2013-03-01 | E-GEOD-42298 | biostudies-arrayexpress
TranscriptomicsRegulation of microRNA Expression and Abundance during Lymphopoiesis
Although the cellular concentration of miRNAs is critical to their function, how miRNA expression and abundance are regulated during ontogeny is unclear. We used deep-sequencing to characterize the microRNome from most developing lymphocytes, various hematopoietic cell lineages, and representative m...
ORGANISM(S): Mus musculus 
2010-06-07 | E-GEOD-21630 | biostudies-arrayexpress
GenomicsRAG Represents a Widespread Threat to the Lymphocyte Genome - (Mnase-seq)
The RAG1 endonuclease, together with its cofactor RAG2, is essential for V(D)J recombination but is a potent threat to genome stability. The sources of RAG1 mistargeting and the mechanisms that have evolved to suppress it are poorly understood. Here, we report the surprising finding that RAG1 bind...
ORGANISM(S): Mus musculus 
2015-08-06 | E-GEOD-69474 | biostudies-arrayexpress
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