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MetabolomicsWhole blood metabolomics of dementia patients reveal classes of disease-linked metabolites

Dementia is caused by factors that damage neurons. We quantified small molecular markers in whole blood of dementia patients, using non-targeted liquid chromatography-mass spectroscopy (LC-MS). Thirty-three metabolites, classified into 5 groups (A-E), differed significantly in dementia patients, ...

2021-07-06 | MTBLS2109 | MetaboLights
UnknownCryo-EM structure of the IS621 recombinase in complex with bridge RNA, left-half DNA, and right-half DNA
Not available
EMPIAR-13446 | biostudies-other
UnknownStructural mechanism of the Retron-Eco7 anti-phage defense system
Not available
EMPIAR-12477 | biostudies-other
UnknownStructural mechanism of RNA-guided RNA editing by the Cas13b-ADAR2 REPAIR complex
Not available
EMPIAR-11850 | biostudies-other
UnknownStructural mechanism of SAM-AMP synthesis by the type III-D2 CRISPR effector complex
Not available
EMPIAR-13321 | biostudies-other
TranscriptomicsGene expression profiles in liver of Sprague-Dawley rat using two types of anesthesia.
To reveal influence of anesthesia in toxicogenomics study, gene expression analysis of liver of Sprague-Dawley rat after isoflurane anesthesia or CO2/O2 anesthesia was performed. The liver samples were excised from each rat after isoflurane anesthesia or CO2/O2 anesthesia. The gene expression profil...
ORGANISM(S): Rattus norvegicus 
2015-07-24 | E-GEOD-71277 | biostudies-arrayexpress
TranscriptomicsmiR-140 deficiency effect on the chondrocytes
Analysis of mouse chondrocytes lacking the microRNA-140. MicroRNAs are genomically encoded small RNAs to regulate the gene expression. miR-140 shows high expression in cartilage. Results provide insight into the molecular mechanisms underlying miR-140 function in chondrocytes. Keywords: Expression ...
ORGANISM(S): Mus musculus 
2010-01-01 | E-GEOD-16007 | biostudies-arrayexpress
TranscriptomicsMepenzolate bromide displays beneficial effects in a mouse model of chronic obstructive pulmonary disease
For the clinical treatment of chronic obstructive pulmonary disease (COPD), it is important not only to improve the airflow limitation by bronchodilation but also to suppress emphysema by controlling inflammation. In this study, we have screened for compounds that prevent elastase-induced airspace ...
ORGANISM(S): Mus musculus 
2013-11-13 | E-GEOD-50836 | biostudies-arrayexpress
UnknownLethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene.
Not available
S-EPMC5398483 | biostudies-literature
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
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