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UnknownNucleophilic reactivity of the gold atom in a diarylborylgold(i) complex toward polar multiple bonds.
A di(o-tolyl)borylgold complex was synthesized via the metathesis reaction of a gold alkoxide with tetra(o-tolyl)diborane(4). The resulting diarylborylgold complex exhibited a Lewis acidic boron center and a characteristic visible absorption that arises from its HOMO-LUMO excita...
S-EPMC8179162 | biostudies-literature
MetabolomicsNiacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma (Cell NAMPTi treatment)

NAMPT plays a major role in NAD biosynthesis in many cancers and is an attractive potential cancer target. However, factors dictating therapeutic efficacy of NAMPT inhibitors (NAMPTi) are unclear. We report that neuroendocrine phenotypes predict lung and prostate carcinoma vulnerability to NAMPTi...

2023-10-10 | MTBLS7251 | MetaboLights
UnknownReactivity of highly Lewis acidic diborane(4) towards pyridine and isocyanide: formation of boraalkene-pyridine complex and ortho-functionalized pyridine derivatives.
The reaction of pinB-BMes2 (pin = pinacolato, Mes = 2,4,6-Me3C6H2) with Xyl-NC (Xyl = 2,6-Me2C6H3) and pyridine results in the formation of a pyridine-coordinated boraalkene that exhibits an intense color caused by an intra...
S-EPMC5887101 | biostudies-literature
UnknownOak Wilt Disease May Reduce the Initial Decay Rate of Dead Quercus serrata Stems by Altering Fungal Communities in the Wood.
Oak wilt causes severe dieback of Quercus serrata, a dominant tree species in the lowlands across Japan. This study evaluated the effects of oak wilt on the wood-inhabiting fungal community and the decay rate of deadwood using a field monitoring experiment. We analysed the fungal metabarcoding commu...
S-EPMC11707560 | biostudies-literature
GenomicsThe Menin–Bach2 axis is critical for regulating CD4 T cell senescence and homeostasis
Although CD4 T cell senescence plays an important role in immunosenescence, the mechanisms remain unclear. We found that T cell-specific Menin deficiency results in the premature senescence of CD4 T cells, accompanied by the senescence-associated secretory phenotype (SASP) after antigenic stimulati...
ORGANISM(S): Mus musculus 
2014-03-27 | E-GEOD-53831 | biostudies-arrayexpress
MetabolomicsClostridium butyricum-induced ω-3 fatty acid 18-HEPE elicits anti-influenza virus pneumonia effects through interferon-λ upregulation

The precise mechanism by which butyrate-producing bacteria in the gut contribute to resistance to respiratory viral infections remains to be elucidated. Here, we describe a gut-lung axis mechanism and report that orally administered Clostridium butyricum (CB) enhances influenza virus infection re...

2023-05-30 | MTBLS4590 | MetaboLights
TranscriptomicsIdentification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFbeta [Agilent]
IL-4 plays an important role in the induction of Th2 and Th9 cells as well as in the inhibition of Th1 cell generation. We herein show that a combination of IL-4 and TGFbeta augment the development of Th1 cells that express CD103 (CD103+ Th1 cells) if IFNgamma is present. The T-box containing tran...
ORGANISM(S): Mus musculus 
2012-03-17 | E-GEOD-36554 | biostudies-arrayexpress
TranscriptomicsIdentification of a new pathway for Th1 cell development induced by cooperative stimulation with IL-4 and TGFbeta [Affymetrix]
IL-4 plays an important role in the induction of Th2 and Th9 cells as well as in the inhibition of Th1 cell generation. We herein show that a combination of IL-4 and TGFbeta augment the development of Th1 cells that express CD103 (CD103+ Th1 cells) if IFNgamma is present. The T-box containing tran...
ORGANISM(S): Mus musculus 
2012-03-17 | E-GEOD-36520 | biostudies-arrayexpress
TranscriptomicsCD109 expression regulates the phenotype of cancer stem-like cells or cancer-initiating cells in epithelioid sarcoma with possible impact on clinical prognosis
Several human cancers contain a small subpopulation of cells called cancer stem-like cells (CSCs)/cancer initiating cells (CICs), which are defined by the ability of self- renewal, multi-differentiation potential, and tumorigenesis. In current study, we focused on epithelioid sarcoma, which is very ...
ORGANISM(S): Homo sapiens 
2014-01-07 | E-MEXP-3826 | biostudies-arrayexpress
TranscriptomicsA novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus
IL-5 is a key cytokine that plays an important role in the development of pathological conditions in chronic allergic inflammation. Identification of a strategy to inhibit IL-5 production is important for establishment of new therapies for allergic inflammation. We found that SH-2251, a novel thio...
ORGANISM(S): Mus musculus 
2013-04-30 | E-GEOD-42131 | biostudies-arrayexpress
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