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TranscriptomicsDeep sequencing and proteomics analysis reveal globally dysregulated expression of microRNA and their target genes in rat kidneys treated by carcinogenic dose of Aristolochic Acid
MicroRNAs (miRNAs) play an important role in carcinogenesis by regulating the protein translation from their targeted messenger RNAs (mRNA). Aristolochic Acid (AA) is a potent carcinogen that can induce kidney tumors in both human and experimental animals. Although the expression and roles of miRN...
ORGANISM(S): Rattus norvegicus 
2012-01-01 | E-GEOD-33703 | biostudies-arrayexpress
TranscriptomicsExpression of microRNAs in rat kidney treated with a carcinogenic dose of Aristolochic Acid
Aristolochic Acid (AA), a natural component of Aristolochia plants found in a variety of herbal remedies and health supplements, is classified as a group 1 carcinogen by the International Agency for Research on Cancer. In order to search for miRNA regulation in AA-induced carcinogenesis, we treated ...
ORGANISM(S): Rattus norvegicus 
2015-01-15 | E-GEOD-54338 | biostudies-arrayexpress
ProteomicsCLOCK regulates Drp1 mRNA stability and mitochondrial homeostasis by interacting with PUF60
This study demonstrated that circadian gene clock plays an important role in the regulation of mitochondrial homeostasis. In this process, CLOCK interacts with PUF60 and affects the mRNA stability of Drp1.
ORGANISM(S): Mus Musculus 
2022-03-31 | PXD032057 |
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