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ProteomicsStratifying the Cell Surface Cysteinome using Two-step Enrichment Proteomics
Cell surface cysteines represent an attractive class of residues for chemoproteomic studies due to their accessibility towards drugs and key roles they play in the structure and function of most human proteins. The redox sensitivity of cysteines also makes cell surface cysteines potential markers fo...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042403 | Pride
Oxidation states T cell activation Cysteines Chemoproteomics Cell surface 
ProteomicsRapid and high coverage profile of human cysteineome
Cysteines play important roles in many biological activities, including protein folding, aging, signaling and etc. To identify and quantitatively profile the oxidation and reactivity of cysteines, cysteine-reactive compounds have been applied to covalently label and enrich the cysteines. And with ma...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023060 | Pride
Faims Cysteine Sp3 Proteomics Lc-ms/ms 
ProteomicsRapid and high coverage profile of human cysteineome-Figure 6
Cysteines play important roles in many biological activities, including protein folding, aging, signaling and etc. To identify and quantitatively profile the oxidation and reactivity of cysteines, cysteine-reactive compounds have been applied to covalently label and enrich the cysteines. And with ma...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023058 | Pride
Faims Cysteine Sp3 Proteomics Lc-ms/ms 
ProteomicsRapid and high coverage profile of human cysteineome-Figure 1
Cysteines play important roles in many biological activities, including protein folding, aging, signaling and etc. To identify and quantitatively profile the oxidation and reactivity of cysteines, cysteine-reactive compounds have been applied to covalently label and enrich the cysteines. And with ma...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023056 | Pride
Faims Cysteine Sp3 Proteomics Lc-ms/ms 
ProteomicsRapid and high coverage profile of human cysteineome-Figure 2
Cysteines play important roles in many biological activities, including protein folding, aging, signaling and etc. To identify and quantitatively profile the oxidation and reactivity of cysteines, cysteine-reactive compounds have been applied to covalently label and enrich the cysteines. And with ma...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023057 | Pride
Faims Cysteine Sp3 Proteomics Lc-ms/ms 
ProteomicsRapid and high coverage profile of human cysteineome
Cysteines play important roles in many biological activities, including protein folding, aging, signaling and etc. To identify and quantitatively profile the oxidation and reactivity of cysteines, cysteine-reactive compounds have been applied to covalently label and enrich the cysteines. And with ma...
ORGANISM(S): Homo sapiens (Human) 
2021-02-03 | PXD023059 | Pride
Faims Cysteine Sp3 Proteomics Lc-ms/ms 
ProteomicsEnhancing Cysteine Chemoproteomic Coverage Through Systematic Assessment of Click Chemistry Product Fragmentation - 2
Higher-energy C-trap dissociation (HCD) of triazole-and biotin-modified peptides affords several characteristic fragment ions, including previously reported and newly identified species. Using the open and mass offset search strategies, we conduct an in-depth analysis of the relative intensities and...
ORGANISM(S): Homo sapiens (Human) 
2022-07-22 | PXD030737 | Pride
Fragmentation Chemoproteomics Diagnostic ions Biotinylation 
ProteomicsProximity-labeling chemoproteomics defines the subcellular cysteinome and inflammation-responsive mitochondrial redoxome
Proteinaceous cysteines function as essential sensors of cellular redox state. Consequently, defining the cysteine redoxome is a key challenge for functional proteomic studies. While proteome-wide inventories of cysteine oxidation state are readily achieved using established, widely adopted proteomi...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-08-10 | PXD039626 | Pride
Cysteine Chemoproteomics Redox sensitive Proximity labeling 
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