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TranscriptomicsChecking the origin utilisation of Haloferax mediterranei H13 through high-throughput DNA sequencing
A potential origin that appears to stay dormant in its native host Haloferax volcanii lacking the main active origins becomes activated and competent for replication of the entire chromosome when integrated into the chromosome of the origin-deleted H. mediterranei. Measurement of replication dynamic...
ORGANISM(S): Haloferax mediterranei 
2015-07-10 | E-GEOD-70592 | biostudies-arrayexpress
TranscriptomicsAdipocyte XBP1s regulates systemic insulin sensitivity by modulating adiponectin multimerization
The physiological role of the spliced form of X-box-binding protein 1 (XBP1s), a key transcription factor of the endoplasmic reticulum (ER) stress response, in adipose tissue remains largely unknown. Here we show that overexpression of XBP1s promotes adiponectin multimerization in adipocytes, thereb...
ORGANISM(S): Mus musculus 
2013-11-21 | E-GEOD-36031 | biostudies-arrayexpress
TranscriptomicsChromosomal origin utilisation in Haloferax meiditerranei wild type and mutant strains
We have comprehensively explored the origin utilisation in Haloferax mediterranei. Here we report three active chromosomal origins by genome-wide replication profiling, and demonstrate that when these three origins are deleted, a dormant origin becomes activated. Genomic DNA was extracted from the H...
ORGANISM(S): Haloferax mediterranei 
2015-07-08 | E-GEOD-70597 | biostudies-arrayexpress
MetabolomicsExtracellular Vesicles from probiotics mediated Walnut green husk polysaccharide alleviates ochratoxin-A-induced cognitive impairment via SCFA and 5-HT mediated microbiota-gut-brain axis

BACKGROUND: Ochratoxin A (OTA) have made it a serious hazard to food safety worldwide that poses a serious health risk to humans. Our previous research showed that Walnut green husk polysaccharides (WGP) can effectively alleviate intestinal inflammation and intestinal microbiota ...

2024-10-10 | MTBLS10673 | MetaboLights
TranscriptomicsThe IRE1α-XBP1 Pathway of the Unfolded Protein Response is Required for Adipogenesis
Signaling cascades during adipogenesis culminate in the expression of two essential adipogenic factors, PPARγ and C/EBPα. Here we demonstrate that the IRE1α-XBP1 pathway, the most conserved branch of the unfolded protein response (UPR), is indispensable for adipogenesis. Indeed, XBP1-deficient ...
ORGANISM(S): Mus musculus 
2010-06-19 | E-GEOD-15771 | biostudies-arrayexpress
TranscriptomicsBCOR controls maintenance of haematopoietic stem cell quiescence and regulates myeloid cell proliferation and differentiation [Illumina]
BCOR is a component of a variant Polycomb group repressive complex 1 (PRC1) complex. Recently, we and others reported recurrent somatic BCOR loss-of-function mutations in myelodysplastic syndrome and acute myelogenous leukaemia (AML). However the role of BCOR in normal hematopoiesis is largely unkno...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-69620 | biostudies-arrayexpress
TranscriptomicsBCOR controls maintenance of haematopoietic stem cell quiescence and regulates myeloid cell proliferation and differentiation [Affymetrix]
BCOR is a component of a variant Polycomb group repressive complex 1 (PRC1) complex. Recently, we and others reported recurrent somatic BCOR loss-of-function mutations in myelodysplastic syndrome and acute myelogenous leukaemia (AML). However the role of BCOR in normal hematopoiesis is largely unkno...
ORGANISM(S): Homo sapiens 
2015-12-31 | E-GEOD-69565 | biostudies-arrayexpress
ProteomicsProteomics dataset of COVID-19 and control patients
Proteomics dataset of COVID-19 and control patients
ORGANISM(S): Homo Sapiens 
PXD029023 |
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