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UnknownRandomized open-label phase II study of decitabine in patients with low- or intermediate-risk myelodysplastic syndromes.
Not available
S-EPMC4878053 | biostudies-literature
TranscriptomicsDNMT3B7, an aberrant DNMT3B isoform, suppresses growth, induces differentiation, and alters DNA methylation in human neuroblastoma
In adult cancers, epigenetic changes and aberrant splicing of the DNMT3B is commonly observed, and the pattern of gene methylation and expression has been shown to be modified by DNMT3B7, a truncated protein of DNMT3B. Much less is known about the mechanism of epigenetic changes in the pediatric ca...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-36350 | biostudies-arrayexpress
TranscriptomicsmodENCODE RNA-Seq of Drosophila cell lines Kc167, CME_W1_Cl.8+, S2-DRSC and ML-DmBG3-c2
Deep Sequencing of mRNA from the Drosophila melanogaster cell lines Kc167, CME_W1_Cl.8+, S2-DRSC and ML-DmBG3-c2. For data usage terms and conditions, please refer to http://www.genome.gov/27528022 and http://www.genome.gov/Pages/Research/ENCODE/ENCODEDataReleasePolicyFinal2008.pdf Analysis of pol...
ORGANISM(S): Drosophila melanogaster 
2009-04-08 | E-GEOD-15596 | biostudies-arrayexpress
ProteomicsProteome analysis of NanoMEDIC particles
CRISPR-Cas9 has tremendous potential as a therapeutic tool for treating human diseases. However, prolonged expression of the nuclease and gRNA from viral vectors in an in vivo context may cause off-target activity and immunogenicity. While extracellular vesicles have been recently demonstrated to be...
ORGANISM(S): Homo Sapiens (human) 
2020-01-30 | PXD014527 | JPOST Repository
GenomicsEGAS00001000165-sc-20150427 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001353 | EGA
GenomicsEGAS00001000902-sc-20150424 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001351 | EGA
GenomicsEGAS00001000160-sc-20150424 - samples
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
EGAD00001001349 | EGA
GenomicsFrequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells
Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm and the mitochondrial double membrane. Despite these physical barriers we show that somatically acquired mitochondrial-nuclear genome fusion sequences are pres...
EGAS00001001234 | EGA
UnknownAn organism-wide ATAC-seq peak catalog for the bovine and its use to identify regulatory variants.
Not available
S-EPMC10691486 | biostudies-literature
UnknownConsistent improvement with eculizumab across muscle groups in myasthenia gravis.
Not available
S-EPMC7448154 | biostudies-literature
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