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TranscriptomicsElevated AKR1C3 expression promotes prostate cancer cell survival and prostate cell-mediated endothelial cell tube formation: Implications for prostate cancer progression
Background: Aldo-keto reductase (AKR) 1C family member 3 (AKR1C3), one of four identified human AKR enzymes, catalyzes steroid, prostaglandin, and xenobiotic metabolism. In the prostate, AKR1C3 is up-regulated in localized and advanced prostate adenocarcinoma, and is associated with prostate cance...
ORGANISM(S): Homo sapiens 
2010-08-10 | E-GEOD-20956 | biostudies-arrayexpress
GenomicsYy1 activity in mouse embryonic stem cells
This SuperSeries is composed of the following subset Series: GSE31784: Expression changes in Yy1 knock down mouse embryonic stem cells GSE31785: Yy1 occupancy of mouse ES cell genome Refer to individual Series
ORGANISM(S): Mus musculus 
2012-01-04 | E-GEOD-31786 | biostudies-arrayexpress
TranscriptomicsExpression changes in Yy1 knock down mouse embryonic stem cells
We have determined the global gene expression upon loss of function of the Yy1 transcription factor in mouse embryonic stem cells Total RNA was extracted from ES cells transiently transfected with yy1-specific or scrampled-control siRNA oligos 48 hr post-transfection.
ORGANISM(S): Mus musculus 
2012-01-04 | E-GEOD-31784 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of PRC1 and PRC2 Polycomb chromatin binding in Drosophila
Polycomb group (PcG) proteins maintain transcriptional repression of developmentally important genes and have been implicated in cell proliferation and stem-cell self-renewal. We used a genome-wide approach to map binding patterns of PcG proteins (Pc, esc and Sce) in Drosophila Kc cells. We found th...
ORGANISM(S): Drosophila melanogaster 
2010-06-11 | E-GEOD-4564 | biostudies-arrayexpress
ProteomicsONECUT2 acts a lineage plasticity driver
Androgen receptor- (AR-) indifference is a mechanism of resistance to hormonal therapy in prostate cancer (PC). Here we demonstrate that ONECUT2 (OC2) activates resistance through multiple drivers associated with adenocarcinoma, stem-like and neuroendocrine (NE) variants. Direct OC2 gene targets inc...
ORGANISM(S): Homo sapiens (Human) 
2024-08-10 | PXD050634 | Pride
Onecut2 Prostate cancer Interactome Lc-ms/ms 
UnknownDiet-induced RKIP downregulation disrupts PC/PE-ER homeostasis to drive MASLD.
Not available
S-EPMC12700885 | biostudies-literature
UnknownCharacterization of a novel TFG variant causing autosomal recessive pure hereditary spastic paraplegia.
Not available
S-EPMC11251477 | biostudies-literature
MetabolomicsModulation of liver metabolism and gut microbiota by Alhagi-honey alleviated heat stress-induced liver damage

Alhagi-honey (AH) is a well-established traditional ethnic medicine with advantageous effects against diarrhea and headaches. We aim to explore the preventive effect of AH on liver damage induced by heat stress (HS) and its underlying mechanism. HS models were established by thermostat, and mice ...

2024-09-23 | MTBLS10021 | MetaboLights
UnknownRapid progressive ALS in a patient with a DNAJC7 loss-of-function mutation.
Not available
S-EPMC7524575 | biostudies-literature
UnknownSpinocerebellar ataxia type 36 in the Han Chinese.
Not available
S-EPMC4830187 | biostudies-literature
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