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ProteomicsComparative characterization of osteoclasts derived from murine bone marrow macrophages and RAW 264.7 cells using quantitative proteomics
Osteoclasts (OCs) are bone-resorbing cells differentiated from macrophage/monocyte precursors in response to M-CSF and RANKL. In vitro models are principally based on primary bone marrow macrophages, but RAW 264.7 cells are frequently used because they are widely available, easy to culture, and more...
ORGANISM(S): Mus musculus (Mouse) 
2018-11-27 | PXD009610 | Pride
Proteomics Raw264.7 Osteoclast Bone marrow macrophages 
ProteomicsUbiquitin Ligase Enzyme FANCL Inhibits Peste des petits ruminants Virus Replication by Inducing Type I Interferon Production through Promoting Phosphorylation of TBK1
Peste des petits ruminants virus (PPRV) infection causes highly contagious and severe disease in domestic and wild ruminants. It is widely reported that PRRV infection causes considerable innate immunosuppression in its host and promotes viral replication. However, how does the host rescue the innat...
ORGANISM(S): Ovis aries 
2021-07-26 | PXD022271 | Pride
Peste des petits ruminants virus  quantitative proteomics  fancl  innate immune response  tbk1 
ProteomicsThe insufficient activation of RIG-I-like signaling pathway in IBRS-2 cells contributes to highly efficient replication of porcine picornaviruses
Seneca Valley Virus (SVV) or commonly known as Senecavirus A (SVA), is one of picornavirus that is associated with vesicular disease and neonatal mortality in swine herds. However, the pathogenesis of SVV remains largely elusive. Our previous study found that SVV replicates extremely faster in porci...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-10-05 | PXD024003 | Pride
Senecavirus a  foot-and-mouth disease virus  rig-i like receptor signaling pathway  interferon  antiviral response 
ProteomicsThe insufficient activation of RIG-I-like signaling pathway in IBRS-2 cells contributes to highly efficient replication of porcine picornaviruses
Seneca Valley Virus (SVV) or commonly known as Senecavirus A (SVA), is one of picornavirus that is associated with vesicular disease and neonatal mortality in swine herds. However, the pathogenesis of SVV remains largely elusive. Our previous study found that SVV replicates extremely faster in porci...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-10-05 | PXD024002 | Pride
Senecavirus a  foot-and-mouth disease virus  rig-i like receptor signaling pathway  interferon  antiviral response 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063537 | Pride
Palmitoylation Senescence 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063840 | Pride
Osteoarthritis Senescence 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis [III]
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063864 | Pride
Osteoarthritis Senescence 
ProteomicsZDHHC11-mediated palmitoylation alleviates chondrocyte senescence and serves as a therapeutic target for osteoarthritis [II]
Osteoarthritis (OA) is a chronic, degenerative whole-joint disorder that interferes with quality of life in older individuals. Here, we report a high expression of ZDHHC11 in articular chondrocytes, which is downregulated in the degenerated cartilage of aged mice and OA patients. ZDHHC11 prevents ch...
ORGANISM(S): Homo sapiens (Human) 
2025-08-12 | PXD063859 | Pride
Osteoarthritis Il-1β 
ProteomicsPeste des petits ruminants virus nucleocapsid protein interacts with PACT and induces stress granule to promote viral replication
Stress granules (SGs) formation is a conserved cellular strategy to reduce stress-related damage regulating cell survival. A Mass spectrometry-based profiling of the interactome of PPRV N protein revealed that PPRV N interacted with PACT to regulate the assembly of SGs. N protein inhibited the inter...
ORGANISM(S): Homo Sapiens 
2022-12-27 | PXD039104 |
ProteomicsA multi-omics dataset of human transcriptome and proteome stable reference
In recent years, the development of high-throughput omics technology has greatly promoted the development of biomedicine. However, the poor reproducibility of omics techniques limits its application. It is necessary to use standard reference materials of complex RNAs or proteins to test and calibrat...
ORGANISM(S): Homo Sapiens 
2023-04-03 | PXD041292 |
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