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TranscriptomicsIdentification of DNA methylation changes in monocytes to osteoclast differentiation
Conversion of monocytes to osteoclasts is a unique terminal differentiation process within the hematopoietic system involving differentiation and massive cell fusion. Here we focused on DNA methylation changes during osteoclastogenesis. Hypermethylation and hypomethylation changes took place in seve...
ORGANISM(S): Homo sapiens 
2013-08-30 | E-GEOD-46648 | biostudies-arrayexpress
MetabolomicsAlcohol-Induced Bone Loss: Driven by Dysregulated Spatial Distribution of Gut Microbiota and PGD2-IL17 Pathway-Mediated Osteoclast Activation

Purpose: Alcohol-induced damage to bone microstructure leads to alcoholic osteopenia (AOP). While prior studies have demonstrated alcohol's negative impact on bone density, the mechanisms by which alcohol induces osteoporosis through immune pathways, gut microbiota dysbiosis, and metabolic altera...

2025-03-28 | MTBLS11887 | MetaboLights
TranscriptomicsComparison expression data from wild-type and NFATc1-deficient osteoclasts
Genetic deletion of Nfatc1 in mice results in profound osteoclast-poor osteopetrosis, a high bone mass state caused by a lack of osteoclast activity. We hypothesized that the family of NFATc1 regulated transcripts in the osteoclast would be enriched for genes associated with osteoclast function. We...
ORGANISM(S): Mus musculus 
2012-08-18 | E-GEOD-37219 | biostudies-arrayexpress
ProteomicsMouse osteoclast secretory lysosomes nLC-ESI-MS/MS
To survey the proteome of osteoclast secretory lysosomes, we used superparamagnetic iron oxide nanoparticles (SPIONs) to enrich for these endo-lysosomal-related organelles from murine osteoclast cultures. Briefly, large scale murine bone marrow monocyte (BMM)-derived osteoclast cultures were ‘pulsed...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-25 | PXD037006 | Pride
Lysosome Lro Mouse Spion Osteoclast Secretory lysosome 
ProteomicsMouse osteoclast secretory lysosomes nLC-ESI-MS/MS - WT vs Slc37a2 KO
To survey the proteome of osteoclast secretory lysosomes, we used superparamagnetic iron oxide nanoparticles (SPIONs) to enrich for these endo-lysosomal-related organelles from murine osteoclast cultures. Briefly, large scale murine bone marrow monocyte (BMM)-derived osteoclast cultures were ‘pulsed...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-25 | PXD037813 | Pride
Lysosome Lro Mouse Spion Osteoclast Secretory lysosome 
TranscriptomicsPathway analysis of microRNA expression profile during murine osteoclastogenesis
Osteoclasts are multinucleated cells specialized in degrading the mineralized bone matrix. Osteoclast differentiation and function are tightly regulated, to prevent excessive or insufficient bone resorption. Several control mechanisms participate in modulating osteoclastogenesis, and an increasing n...
ORGANISM(S): Mus musculus 
2015-12-31 | E-GEOD-53017 | biostudies-arrayexpress
ProteomicsHuman osteoclast derived from SAPHO PBMC
Inducing the PBMCs from SAPHO patients differentiation into osteoclasts while stimulating with serum exosomes. Compared with exosomes from normal volunteer, we found that about 2/3 of patients’ osteoclast differentiation were inhibited in response to exosomes from SAPHO patients. We present a TMT-la...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD012218 | Pride
Proteomics Sapho Osteoclast 
ProteomicsMouse osteoclast homogenates nLC-ESI-MS/MS - WT vs Slc37a2 KO
To survey the proteomic differences between WT and Slc37a2 knockout osteoclasts at the whole cell and secretory lysosome levels, we used superparamagnetic iron oxide nanoparticles (SPIONs) to enrich for these endo-lysosomal-related organelles from murine osteoclast cultures. Briefly, large scale mur...
ORGANISM(S): Mus musculus (Mouse) 
2023-01-25 | PXD037910 | Pride
Lysosome Lro Mouse Spion Osteoclast Secretory lysosome 
ProteomicsCharacterization of functional reprogramming during osteoclast development using quantitative proteomics and mRNA profiling
Supplemental data for the article: Characterization of functional reprogramming during osteoclast development using quantitative proteomics and mRNA profiling Eunkyung An, Manikandan Narayanan, and Aleksandra Nita-Lazar* *corresponding author: Cellular Networks Proteomics Unit Laboratory of Systems ...
ORGANISM(S): Mus musculus (Mouse) 
2014-07-22 | PXD000471 | Pride
Lc-msms Mouse Osteoclast Triple silac 
ProteomicsELMO1 signaling is a promoter of osteoclast function and bone loss
Osteoporosis and bone fractures affect millions of men and women worldwide and are often due to increased bone resorption (bone loss) mediated by osteoclasts. Here, we identify a novel role for the cytoplasmic protein ELMO1 as an important ‘signaling node’ controlling the bone resorption function of...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD023578 | Pride
Bone loss Osteoclasts Elmo1 Gelc-ms 
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