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ProteomicsELMO1 signaling is a promoter of osteoclast function and bone loss
Osteoporosis and bone fractures affect millions of men and women worldwide and are often due to increased bone resorption (bone loss) mediated by osteoclasts. Here, we identify a novel role for the cytoplasmic protein ELMO1 as an important ‘signaling node’ controlling the bone resorption function of...
ORGANISM(S): Homo sapiens (Human) 
2021-06-07 | PXD023578 | Pride
Bone loss Osteoclasts Elmo1 Gelc-ms 
GenomicsTranscriptome analysis of wildtype elmo1+/+ and homozygous elmo1-/- knockout zebrafish larvae at 120 hpf through next generation RNA sequencing [dataset 1]
Transcriptome analysis of wildtype elmo1+/+ and homozygous elmo1-/- knockout zebrafish larvae at 120 hpf through next generation RNA sequencing [dataset 1]
PRJNA812404 | ENA
GenomicsELMO1 is a promoter of osteoclast function and bone loss
ELMO1 is a promoter of osteoclast function and bone loss
PRJNA692169 | ENA
GenomicsIncreased Elmo1 Expression worsens the AKI-CKD transition via ROS
Increased Elmo1 Expression worsens the AKI-CKD transition via ROS
PRJNA1299412 | ENA
GenomicsEngulfment gene ELMO1 in neutrophils as a promoter of inflammatory arthritis
Engulfment gene ELMO1 in neutrophils as a promoter of inflammatory arthritis
PRJNA505064 | ENA
ProteomicsIdentification of the cross-linked ELMO1-DOCK5-Rac1 complex.
The ELMO1-DOCK5-Rac1 complex is a dimer of heterotrimers centered on a homodimer of the DOCK5 DHR-2 domain. We analyzed the ELMO1-DOCK5-Rac1 complex by cross-linking mass spectrometry and identified intermolecular cross-links between Rac1, ELMO1, and DOCK5.
ORGANISM(S): Homo Sapiens (human) 
2021-05-25 | PXD026097 | JPOST Repository
TranscriptomicsTranscriptome analysis of wildtype elmo1+/+ and homozygous elmo1-/- knockout zebrafish larvae at 120 hpf through next generation RNA sequencing [dataset 1]
Elmo1 is one member of the Elmo protein family. In our study we addressed the question if the functions of Elmo1, Elmo2 and Elmo3 are consistent or if they differ. With the CRISPR/Cas9 system we generated single knockout mutants of elmo1, elmo2 and elmo3 in the zebrafish. To assess the impact of the...
ORGANISM(S): Danio rerio 
2022-07-25 | GSE197824 | GEO
TranscriptomicsELMO1 is a promoter of osteoclast function and bone loss
Osteoporosis and bone fractures affect millions of men and women worldwide and are often due to increased bone resorption (bone loss) mediated by osteoclasts. Here, we identify a novel role for the cytoplasmic protein ELMO1 as an important ‘signaling node’ controlling the bone resorption function of...
ORGANISM(S): Mus musculus 
2021-06-05 | GSE164826 | GEO
ProteomicsCrosslinking MS of Elmo1,Dock5,Rac1 and RhoG complexes
Crosslink mass spectrometry of Elmo1,Dock5,Rac1 and RhoG complexes using BS3 crosslinker.
ORGANISM(S): Homo Sapiens (human) 
2025-01-18 | PXD048862 | JPOST Repository
TranscriptomicsEngulfment gene ELMO1 in neutrophils as a promoter of inflammatory arthritis
Rheumatoid arthritis is an inflammatory disease of the synovial joints that affects ~1% of the human population, with severe distress due to progressive joint inflammation and deformation. When addressing the links between specific components of the apoptotic cell clearance machinery and human disea...
ORGANISM(S): Mus musculus 
2019-03-19 | GSE122412 | GEO
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