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ProteomicsThe deubiquitinase USP13 maintains cancer cell stemness by promoting FASN stability in small cell lung cancer
USP13 is significantly amplified in over 20% of lung cancer patients and critical for tumor progression. However, the functional role of USP13 in small cell lung cancer (SCLC) remains largely unclear. In this study, we found that the deubiquitinase USP13 is highly expressed in SCLC tumor samples and...
ORGANISM(S): Homo Sapiens 
2022-04-06 | PXD032993 |
ProteomicsProteomic profiling of the global protein changes of Neuro-2a cells treated with dFUS-E9C or control
We conducted unbiased mass spectrometric experiments to evaluate the specificity of dFUS-E9C. In these studies, Neuro-2a cells were treated with dFUS-E9C. The result revealed the detection of more than 5000 proteins, among which there was a notable degradation of FUS, confirming the targeted action ...
ORGANISM(S): Mus Musculus 
2025-04-04 | PXD062671 |
ProteomicsProteomic profiling of the global protein changes of Neuro-2a cells treated with siFUS or control
We conducted unbiased mass spectrometric experiments to evaluate the specificity of siFUS. In these studies, Neuro-2a cells were treated with siFUS. The result revealed the detection of more than 5000 proteins, among which there was a notable degradation of FUS, confirming the targeted action of siF...
ORGANISM(S): Mus Musculus 
2025-04-07 | PXD062670 |
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