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MetabolomicsMetabolic Dynamics of In Vitro CD8+ T Cell Activation

CD8+ T cells detect and kill virally infected or cancerous cells. When activated from their naïve state, T cells undergo a complex transition, including major metabolic reprogramming. Detailed resolution of metabolic dynamics of a wide range of metabolites is needed to advance the field of immuno...

2021-06-02 | MTBLS2145 | MetaboLights
GenomicsINSPIRE - Investigator-initiated Phase 2 Study of Pembrolizumab Immunological Response in Metastatic Solid Tumors
Whole exome and RNA sequencing source data for: Clouthier, D.L., Lien, S.C., Yang, S.Y.C. et al. An interim report on the investigator-initiated phase 2 study of pembrolizumab immunological response evaluation (INSPIRE). j. immunotherapy cancer 7, 72 (2019). https://doi.org/10.1186/s40425-019-0541-...
EGAS00001003280 | EGA
UnknownRisk of Early Mortality in Patients With Newly Diagnosed Multiple Myeloma.
Not available
S-EPMC5058940 | biostudies-literature
MetabolomicsTwo Poplar-Associated Bacterial Isolates Induce Additive Favorable Responses in a Constructed Plant-Microbiome System
The biological function of the plant-microbiome system is the result of contributions from the host plant and microbiome members. The Populus root microbiome is a diverse community that has high abundance of β- and γ-Proteobacteria, both classes which include multiple plant-growth promoting represen...
2017-07-25 | MTBLS332 | MetaboLights
MetabolomicshRUV: Hierarchical approach to removal of unwanted variation for large-scale metabolomics data
Liquid chromatography-mass spectrometry-based metabolomics studies are increasingly applied to large population cohorts, which run for several weeks or even years in data acquisition. This inevitably introduces unwanted intra- and inter-batch variations over time that can overshadow true biological ...
2021-07-05 | MTBLS2483 | MetaboLights
UnknownHuman Cytokine Genetic Variants Associated With HBsAg Reverse Seroconversion in Rituximab-Treated Non-Hodgkin Lymphoma Patients.
Not available
S-EPMC4839912 | biostudies-literature
ProteomicsTraffic jam directly regulates the Drosophila piRNA cluster flamenco and the Piwi pathway gene network to ensure transposon silencing and female fertility.
The flamenco (flam) locus is the most prominent piRNA cluster locus expressed in Drosophila ovarian follicle cells that is required for female fertility and silencing of gypsy/mdg4 transposons. Although P-element insertions in the flam promoter region disrupts flam piRNAs and cause female infertilit...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-04-01 | PXD052946 | Pride
Transcription Tmt Multiplexed proteomics Traffic jam Affinity enrichment Transposon Pirna Fertilitym transposon Drosophila melanogaster 
UnknownLatent Tuberculosis Infection and the Risk of Subsequent Cancer.
Not available
S-EPMC5291550 | biostudies-literature
UnknownDevelopmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants.
Not available
S-EPMC4658282 | biostudies-literature
UnknownEstrogen receptor beta signaling in CD8+ T cells boosts T cell receptor activation and antitumor immunity through a phosphotyrosine switch.
Not available
S-EPMC7816924 | biostudies-literature
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