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ProteomicsIntra-tumoral injection of caerin 1.1 and 1.9 peptides in vaccinated TC-1 tumour bearing mice with PD-1 blockade
Development of a vaccine formula that alters the tumour-infiltrating lymphocytes to be more immune active against a tumour is key to the improvement of clinical responses to immunotherapy. Here, we demonstrate that, in conjunction with E7 antigen specific immunotherapy, and IL-10 and PD-1 blockade, ...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-18 | PXD021264 | Pride
T cell Macrophage Pd-1 blockade Caerin peptides Tmt10plex Tc-1 
ProteomicsHost-defence peptides caerin 1.1 and 1.9 stimulate TNF-alpha-dependent apoptosis in human cervical cancer HeLa cells
TNFα pathway has been recognised as one of the most important signalling pathways characterising molecules with anti-cancer activity, due to it closely relates to cell survival as well as apoptosis. Isolated from the glandular secretion of Australian tree frogs, the genus Litoria, host-defence caeri...
ORGANISM(S): Homo sapiens (Human) 
2020-08-27 | PXD015975 | Pride
Proteomics Hela cell Tmt labelling Tnfα signalling pathway Caerin peptide Apoptosis Confocal microscopy Western blot 
ProteomicsDetect the shared protein components between spider dragline silk and silkworm cocoon by Label free quantitative proteomics
The spider major ampullate gland and silkworm silk gland have similar morphological structure and function, so we explored whether there are some common protein components on silks, with three biological replicates for each sample. Dragline silk samples from mature female Trichonephila clavata spide...
ORGANISM(S): Bombyx Mori Trichonephila 
2022-12-09 | PXD038734 |
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