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ProteomicsMulti-omics identification of key targets for the osteogenic differentiation of human bone marrow mesenchymal stromal cells under oxidative stress
Background: Human bone marrow mesenchymal stromal cells (hBMSCs) are multipotent stromal cells capable of osteogenic differentiation, making them a promising cell source for bone tissue engineering and regenerative medicine. Identifying key factors that regulate hBMSCs osteogenic differentiation is ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD067569 | Pride
Osteogenic differentiation Proteomics Bone marrow mesenchymal stromal cells Oxidative stress Transcriptomics 
UnknownIdentification of niclosamide as a novel antiviral agent against porcine epidemic diarrhea virus infection by targeting viral internalization.
Not available
S-EPMC10176444 | biostudies-literature
UnknownNeoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial.
Not available
S-EPMC6145832 | biostudies-literature
UnknownMammalian-brain-inspired neuromorphic motion-cognition nerve achieves cross-modal perceptual enhancement.
Not available
S-EPMC10008641 | biostudies-literature
UnknownIdentification of a conserved G-quadruplex within the E165R of African swine fever virus (ASFV) as a potential antiviral target.
Not available
S-EPMC11261444 | biostudies-literature
ProteomicsCKB catalyzes BCAR1 phosphorylation to regulate DNA damage repair
Creatine kinase (CK) is an essential metabolic enzyme mediating creatine/phosphocreatine interconversion and shuttle to replenish ATP for energy needs. Ablation of CK causes deficiency in energy supply that eventually results in reduced muscle burst activity and neurological disorders in mice. Besid...
ORGANISM(S): Homo Sapiens 
2023-04-05 | PXD041365 |
ProteomicsNeuroprotective Effects of Desert Organic Milk Exosomes Against LPS-Induced Cognitive Impairment: Involvement of Microglial M2 Polarization and AMPK Signaling
Hippocampal neuroinflammation (HNF) is a key pathological feature in neurodegenerative disorders. Milk-derived exosomes are bioactive extracellular vesicles, yet their potential to regulate neuroinflammatory responses in the brain remains underexplored. This study aimed to characterize the superior ...
ORGANISM(S): Bos Taurus 
2025-12-11 | PXD071863 |
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
UnknownAdvances in the Application of Perovskite Materials.
Not available
S-EPMC10333173 | biostudies-literature
ProteomicsDissection of Blood Ecosystem in SARS-CoV-2 Omicron Patients
Here, we systematically profiled clinical phenomes, transcriptomes, proteomes, metabolomes, and immune repertoire of blood cells or plasma in over 1000 specimens from SARS-CoV-2 Omicron patients across multiple disease phases.
ORGANISM(S): Homo Sapiens 
2024-08-02 | PXD045174 |
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