As the most life-threatening subtype of pediatric medulloblastoma (MB), MYC-amplified Group 3 (G3) MB lacks effective and selective therapeutics. We tried to indirectly target MYC (oncogenic driver and cancer-dependent molecule) production via inhibiting translational machinery. Through multiple dat...
Necroptosis is a newly discovered form of programmed cell death (PCD) showing necrotic features, including membrane permeabilization and the release of damage-associated molecular patterns (DAMPs). Studies have revealed both its tumorigenic role and therapeutic potential in various cancers, yet its ...
Brain tissue is extremely sensitive to hypoxia/reoxygenation (H/R) injury, which can easily cause irreversible damage to neurons. H/R injury could induce neuronal apoptosis through glutamate-mediated excitotoxicity. N-methyl-d-aspartate receptor (NMDAR) is one of the main receptors of excitatory glu...
Although people of all ages are susceptible to COVID-19, children usually develop less severe disease than adults. Little is known about the pathogenesis of COVID-19 in children. Herein, we conduct the plasma proteomic and metabolomic profiling of a cohort of COVID-19 children patients with mild sym...
Precise regulation of mitochondrial fusion and fission is essential for cellular activity and animal development. Imbalances between these processes can lead to fragmentation and loss of normal membrane potential in individual mitochondria. In this study, we show that MIRO-1 is stochastically elevat...
After LAPTM5 was overexpressed in rat renal tubular epithelial cells (NRK52E), proteomic sequencing was performed to analyze aging and fibrosis protein changes.
Quantitative proteomic analysis of plasma from different time courses of fatal, severe, and mild COVID-19 patients was performed to assess the biological changes during treatment.
Myelin aging is a driving force of CNS aging, and age-dependent declined efficiency of remyelination caused by impaired differentiation capacity of aged oligodendrocyte precursor cell (OPC) is a major cause of demyelinated diseases. Revealing how differentiation capacity of aged OPC is affected meta...
