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MetabolomicsSacha inchi oil alleviates gut microbiota dysbiosis and improves hepatic lipid dysmetabolism in high-fat diet-fed rats
Dietary ω-3 polyunsaturated fatty acids (PUFAs) are beneficial for humans against the development of hyperlipidaemia, but the underlying mechanisms are still poorly understood. Here, we demonstrated that oral consumption of sacha inchi oil, which is rich in α-linolenic acid, alleviated dyslipidemia,...
2022-02-21 | MTBLS1225 | MetaboLights
MetabolomicsVGLL4 modulates Paneth cells and sustains intestinal homeostasis.
Paneth cells are defensive cells in the intestinal tract, which secrete niche factors and antimicrobial peptides (AMPs) to maintain the small intestinal stem cell niche and immune homeostasis. Here, we show that Vestigial-like family member 4 (VGLL4) plays a pivotal role in maintaining small intesti...
2026-03-12 | MTBLS10456 | MetaboLights
ProteomicsData-Independent Acquisition Mass Spectrometry Identification of Serum-derived Extracellular Vesicle Proteomics for Gastric Adenocarcinoma
Timely diagnosis of gastric adenocarcinoma (GAC) can effectively prevent the deterioration of the disease and significantly improve the survival rate of patients. Currently, tumor markers used in clinical practice cannot meet the needs of patients, and it is urgent to develop biomarkers with high se...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD027535 | Pride
Proteomics Extracellular vesicles Serum Gastric adenocarcinoma 
ProteomicsIdentification of OTUD3 interactors in esophageal cancer cell line
Immunoprecipitation of OTUD3 interacting proteins was subjected to SDS-PAGE, silver-stained, and identified by mass spectrometry (MS).
ORGANISM(S): Homo Sapiens 
PXD028751 |
ProteomicsIdentification of ATP9A interactors in 293T cell line
Macropinocytosis is an effective strategy against nutrient starvation, which fuels cancer cells grow in nutrient-limited conditions. However, whether and how macropinocytosis contributes to the rapid proliferation of hepatocellular carcinoma cells that frequently exhibit inadequate nutrient supply r...
ORGANISM(S): Homo Sapiens 
2022-12-13 | PXD038797 |
ProteomicsIdentification of ADAM10 interactors and N-glycosylation sites in SK-BR-3 cells
Immunoprecipitation of ADAM10-WT and ADAM10-4NQ interacting proteins were identified by mass spectrometry(MS));purified ADAM10 protein was subjected to Coomassie Blue Staining and LC-MS/MS in order to identify the N-glycosylation sites
ORGANISM(S): Homo Sapiens 
2022-07-16 | PXD035378 |
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