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TranscriptomicsDUX4 activates germline genes, retroelements and immune-mediators: Implications for facioscapulohumeral dystrophy
Facioscapulohumeral dystrophy (FSHD) is one of the most common inherited muscular dystrophies. The causative gene remains controversial and the mechanism of pathophysiology unknown. Here we identify genes associated with germline and early stem cell development as targets of the DUX4 transcription f...
ORGANISM(S): Homo sapiens 
2012-01-03 | E-GEOD-33799 | biostudies-arrayexpress
UnknownCytogenetic prognostication within medulloblastoma subgroups.
Not available
S-EPMC3948094 | biostudies-literature
TranscriptomicsTranscription profiling by array of human chromophobe renal cell carcinoma and oncocytoma
This study aims to compare gene expression profiles of chromophobe renal cell carcinoma (RCC) and benign oncocytoma, aiming at identifying differentially expressed genes. Experiment Overall Design: Nine cases each of chromophobe RCC and oncocytoma were analyzed by oligonucleotide microarray. Candid...
ORGANISM(S): Homo sapiens 
2008-10-21 | E-GEOD-12090 | biostudies-arrayexpress
GenomicsConversion of MyoD to a neurogenic factor: binding site specificity determines lineage [ChIP-seq]
MyoD and NeuroD2 are master regulators of myogenesis and neurogenesis and bind to a "shared" E-box sequence (CAGCTG) and a "private" sequence (CAGGTG or CAGATG, respectively). To determine whether private-site recognition is sufficient to confer lineage-specification, we generate...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-64626 | biostudies-arrayexpress
TranscriptomicsConversion of MyoD to a neurogenic factor: binding site specificity determines lineage [RNA-seq]
MyoD and NeuroD2 are master regulators of myogenesis and neurogenesis and bind to a "shared" E-box sequence (CAGCTG) and a "private" sequence (CAGGTG or CAGATG, respectively). To determine whether private-site recognition is sufficient to confer lineage-specification, we generate...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-64622 | biostudies-arrayexpress
TranscriptomicsRetroelements and DUX4 Create Primate-specific Promoters for Germline Genes
The human double-homeodomain retrogene DUX4 is normally expressed at high levels in germ cells of the testis. When aberrantly expressed in muscle its protein product causes facioscapulohumeral muscular dystrophy (FSHD), perhaps partly by inducing inappropriate expression of germline genes. DUX4 can ...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-45883 | biostudies-arrayexpress
TranscriptomicsmiR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells (miRNA)
Background: Similar to replicating myoblasts, many rhabdomyosarcoma cells express the myogenic determination gene MyoD. In contrast to myoblasts, rhabdomyosarcoma cells do not make the transition from a regulative growth phase to terminal differentiation. Previously we demonstrated that the forced e...
ORGANISM(S): Homo sapiens 
2012-04-01 | E-GEOD-35606 | biostudies-arrayexpress
TranscriptomicsmiR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells
This SuperSeries is composed of the following subset Series: GSE35491: miR-206 integrates multiple components of differentiation pathways to control the transition from growth to differentiation in rhabdomyosarcoma cells (Illumina) GSE35606: miR-206 integrates multiple components of differentiation ...
ORGANISM(S): Homo sapiens 
2012-04-01 | E-GEOD-35921 | biostudies-arrayexpress
GenomicsDistinct activities of Myf5 and MyoD indicate sequential roles in skeletal muscle lineage specification and differentiation (ChIP-Seq)
In this work we compare the molecular functions of Myf5 and MyoD, two highly related bHLH transcription factors that regulate skeletal muscle specification and differentiation. We find MyoD and Myf5 bind the same sites genome-wide but have distinct functions: Myf5 induces histone acetylation without...
ORGANISM(S): Mus musculus 
2016-03-01 | E-GEOD-75370 | biostudies-arrayexpress
UnknownThe landscape of viral associations in human cancers.
Not available
S-EPMC8076016 | biostudies-literature
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