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TranscriptomicsKRAS and YAP1 converge to regulate EMT and tumor survival
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. To identify genes that can functionally substitute for oncogenic RAS, we systematically ex...
ORGANISM(S): Mus musculus 
2014-07-27 | E-GEOD-56175 | biostudies-arrayexpress
GenomicsYAP1 exerts its transcriptional control via TEAD mediated activation of enhancers
YAP is the principle effector of the Hippo signaling pathway; a key regulator of tissue homeostasis whose dysregulation is linked to cancer development. YAP regulation of gene expression is thought to involve the TEAD transcription factor family. Here we show that YAP and TEAD1 binding always co-occ...
ORGANISM(S): Homo sapiens 
2015-08-25 | E-GEOD-61852 | biostudies-arrayexpress
GenomicsThe Hippo tranducer YAP1 transforms activated satellite cells and is a potent effector of embryonal rhabdomyosarcoma formation
The Hippo pathway effector YAP1 controls stem cell fate in epithelial tissues, but its role in stem cells of non-epithelial tissues, such as skeletal muscle, is poorly documented. Here we show that sustained YAP1 activity in mouse activated satellite cells in vivo induces rhabdomyosarcoma (RMS) rese...
ORGANISM(S): Homo sapiens 
2014-08-12 | E-GEOD-55186 | biostudies-arrayexpress
TranscriptomicsRescue of KRAS suppression in HCT116 colon cancer cell line
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but the molecular basis of this oncogene dependency remains incompletely understood. To identify genes that can functionally substitute for oncogenic RAS, we systematically ex...
ORGANISM(S): Homo sapiens 
2014-07-22 | E-GEOD-55942 | biostudies-arrayexpress
GenomicsA Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment
A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment
PRJNA1129119 | ENA
GenomicsYAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast [scRNA-seq]
YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast [scRNA-seq]
PRJNA1180567 | ENA
GenomicsYAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast [ChIP-seq]
YAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast [ChIP-seq]
PRJNA1180568 | ENA
UnknownYAP1 and QSER1 are Key Modulators of Embryonic Signaling Pathways in the Mammalian Epiblast.
Not available
S-EPMC12262321 | biostudies-literature
UnknownA retinoic acid:YAP1 signaling axis controls atrial lineage commitment.
Not available
S-EPMC12186250 | biostudies-literature
UnknownNEDD8 enhances Hippo signaling by mediating YAP1 neddylation.
Not available
S-EPMC11327456 | biostudies-literature
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