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ProteomicsA non-canonical function of tyrosyl-tRNA synthetase in actin bundling
Aminoacyl-tRNA synthetases are the largest protein family implicated in Charcot-Marie-Tooth disease (CMT), the most common inherited peripheral neuropathy that is currently incurable. These essential enzymes catalyze the attachment of amino acids to their cognate tRNAs, thereby enabling the protein ...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD037630 | Pride
Yars Hek293t cells 
UnknownA Novel Homozygous Missense Mutation in the YARS Gene: Expanding the Phenotype of YARS Multisystem Disease.
Not available
S-EPMC7806200 | biostudies-literature
UnknownAn Expanded Multi-Organ Disease Phenotype Associated with Mutations in YARS.
Not available
S-EPMC5748699 | biostudies-literature
UnknownYARS as an oncogenic protein that promotes gastric cancer progression through activating PI3K-Akt signaling.
Not available
S-EPMC6985085 | biostudies-literature
UnknownHomozygosity for a mutation affecting the catalytic domain of tyrosyl-tRNA synthetase (YARS) causes multisystem disease.
Not available
S-EPMC6360277 | biostudies-literature
UnknownAnatomical distributional defects in mutant genes associated with dominant intermediate Charcot-Marie-Tooth disease type C in an adenovirus-mediated mouse model.
Not available
S-EPMC5399729 | biostudies-literature
UnknownKnockdown of SIRT2 Rescues YARS-induced Charcot-Marie-Tooth Neuropathy in Drosophila.
Not available
S-EPMC11004100 | biostudies-literature
UnknownCombined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer.
Not available
S-EPMC7687715 | biostudies-literature
UnknownReplating induces mTOR-dependent rescue of protein synthesis in Charcot-Marie-Tooth diseased neurons.
Not available
S-EPMC12407962 | biostudies-literature
UnknownSelection of reliable reference genes for gene expression study in nasopharyngeal carcinoma.
Not available
S-EPMC4003330 | biostudies-literature
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