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GenomicsGenome-wide map of BACH1 binding in HEK 293T cells
BTB and CNC homology 1 (BACH1) is a heme-binding transcription factor repressing the transcription from a subset of MAF recognition elements (MAREs) at low intracellular heme levels. Upon heme binding, BACH1 is released from the MAREs, resulting in increased expression of antioxidant response genes....
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-28051 | biostudies-arrayexpress
ProteomicsRUNX1 isoforms in leukemogenesis
Aneuploidy and structural aberrations affecting chromosome 21 (Hsa21) are the most frequent in cytogentic events in acute myeloid leukemia. However, it remains unclear why leukemic blasts select for amplifications of Hsa21 or parts of it and why children with Down syndrome (i.e. trisomy 21) are at a...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD030616 | Pride
Down syndrome Runx1 Acute myeloid leukemia Gata1 Transient abnormal myelopoiesis 
TranscriptomicsExpression data from knockdown of BACH1 in HEK 293T cells
BTB and CNC homology 1 (BACH1) is a heme-binding transcription factor repressing the transcription from a subset of MAF recognition elements (MAREs) at low intracellular heme levels. Upon heme binding, BACH1 is released from the MAREs, resulting in increased expression of antioxidant response genes....
ORGANISM(S): Homo sapiens 
2011-05-13 | E-GEOD-28050 | biostudies-arrayexpress
GenomicsOncotrack DAC
Data Access Committee EGAC00001000469
EGAC00001000469 | EGA
UnknownRUNX1 isoform disequilibrium promotes the development of trisomy 21-associated myeloid leukemia.
Not available
S-EPMC10023736 | biostudies-literature
UnknownInhibiting H3K27 Demethylases Downregulates CREB-CREBBP, Overcoming Resistance in Relapsed Acute Lymphoblastic Leukemia.
Not available
S-EPMC11719120 | biostudies-literature
GenomicsWGSeq_HealthyHuman_DATA_SET_xmas_MB_2013_07_10 - samples
HSC73_clone: Bone marrow mononuclear cells from the healthy 73 years old female were thawed and labeled with Alexa-Fluor 488-conjugated anti-CD34 (581, Biolegend), Alexa-Fluor 700-conjugated anti-CD38 (HIT2, eBioscience), a cocktail of APC-conjugated lineage antibodies consisting of anti-CD4 (RPA-T4...
EGAD00001000666 | EGA
UnknownMechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Not available
S-EPMC6863161 | biostudies-literature
TranscriptomicsRole of BACH1 in HEK 293T cells
This SuperSeries is composed of the following subset Series: GSE28050: Expression data from knockdown of BACH1 in HEK 293T cells GSE28051: Genome-wide map of BACH1 binding in HEK293T cells Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-05-12 | E-GEOD-28053 | biostudies-arrayexpress
UnknownMyeloid leukemia vulnerabilities embedded in long noncoding RNA locus MYNRL15.
Not available
S-EPMC10520325 | biostudies-literature
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