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TranscriptomicsGene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib). BCR-ABL1 t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20987 | biostudies-arrayexpress
TranscriptomicsGene expression data of interleukin-7-dependent and BCR-ABL1-transformed pre-B cells
This analysis focused on identifying factors that protect pre-B cells against DNA double strand break (DSB)-mediated DNA damage stress during pre-B cell differentiation. Differentiation of pre-B cells including immunoglobulin light chain gene recombination were performed by withdrawal of interleuki...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21664 | biostudies-arrayexpress
TranscriptomicsTargeting the MTOR-AKT pathway in DLBCL
The mTOR (mammalian Target of Rapamycin) pathway is constitutively activated in Diffuse Large B-Cell Lymphoma (DLBCL). mTOR inhibition has been shown to have clinical activity in patients with DLBCL, although overall response rates remain low. We therefore evaluated differences in the transcriptome...
ORGANISM(S): Homo sapiens 
2012-04-29 | E-GEOD-27255 | biostudies-arrayexpress
UnknownCoordinated regulation of BACH1 and mitochondrial metabolism through tumor-targeted self-assembled nanoparticles for effective triple negative breast cancer combination therapy.
Not available
S-EPMC9532561 | biostudies-literature
UnknownIL-21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp-1 in human B cells.
Not available
S-EPMC3563840 | biostudies-literature
UnknownPre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC.
Not available
S-EPMC3204735 | biostudies-literature
UnknownSTAT3 Inhibitor ODZ10117 Suppresses Glioblastoma Malignancy and Prolongs Survival in a Glioblastoma Xenograft Model.
Not available
S-EPMC7140655 | biostudies-literature
UnknownTrichomonas vaginalis Induces SiHa Cell Apoptosis by NF-κB Inactivation via Reactive Oxygen Species.
Not available
S-EPMC5748870 | biostudies-literature
TranscriptomicsArray CGH between GK and Wistar Rats for Detecting Copy Number Variations
The Goto-Kakizak (GK) rat, a nonobese animal model of Type 2 diabetes (T2D), were developed by repeated inbreeding of glucose-intolerent individuals selected from Wistar rats. During their development, GK rats suffer from reduced beta-cell mass and insulin resistance spontaneously (T2D phenotype), w...
ORGANISM(S): Rattus norvegicus 
2010-12-31 | E-GEOD-21387 | biostudies-arrayexpress
ProteomicsAPEX proximity labeling of murine NDUFS4 interacting proteins in podocytes
In this project we used an unbiased approach to identify the proteins that interact with NDUFS4 in the mouse podocytes using the APEX2 proximity labeling system. An immortalized murine podocyte was permanently transduced with a doxycycline (DOX) inducible NDUFS4-APEX2 chimeric construct. The cells w...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-08 | PXD041378 | Pride
Apex proximity labeling of murine ndufs4 interacting proteins in podocytes 
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