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TranscriptomicsNatural Variation and Timing of Stress Responses Promote and Predict Heterosis
Hybrid plants and animals grow larger and more vigorously than the parents, a common phenomenon known as hybrid vigor or heterosis. Heterosis often correlates with the genetic distance between hybridizing parents, but the mechanism for this is largely unknown. We found that genetic distance was corr...
ORGANISM(S): Arabidopsis thaliana 
2015-05-31 | E-GEOD-51578 | biostudies-arrayexpress
GenomicsHigh definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing
DNA methylation stabilizes developmentally programmed gene expression states. Aberrant methylation is associated with disease progression and is a common feature of cancer genomes. Presently, few methods enable quantitative, large-scale, single-base resolution mapping of DNA methylation states in d...
ORGANISM(S): Homo sapiens 
2009-07-08 | E-GEOD-17001 | biostudies-arrayexpress
UnknownAstilbin prevents bone loss in ovariectomized mice through the inhibition of RANKL-induced osteoclastogenesis.
Not available
S-EPMC6850941 | biostudies-literature
TranscriptomicsSox4 is a key oncogenic target in C/EBP? mutant Acute Myeloid Leukemia
Mutation or epigenetic silencing of the transcription factor C/EBP? is observed in ~10% of patients with acute myeloid leukemia (AML). In both cases, a common global gene expression profile is observed, but down-stream targets relevant for leukemogenesis are not known. Here we identify Sox4 as a dir...
ORGANISM(S): Mus musculus 
2013-03-23 | E-GEOD-45430 | biostudies-arrayexpress
TranscriptomicsHNRNPU RNA targets and DNA methylation changes during neural differentiation
This study investigates the molecular mechanisms by which the DNA/RNA-binding protein HNRNPU regulates gene expression during early human neural development. Pathogenic variants in HNRNPU cause a severe neurodevelopmental disorder, but the underlying mechanisms remain poorly understood. To explore t...
ORGANISM(S): Homo sapiens 
2026-02-02 | E-MTAB-14910 | biostudies-arrayexpress
TranscriptomicsSystematic evaluation of variability in simulated ChIP-chip experiments
The most widely-used method for detecting and measuring genome-wide protein-DNA interactions is chromatin immunoprecipitation on tiling microarrays, commonly known as ChIP-chip. Many tiling array platforms, amplification methods, and analysis algorithms exist for ChIP-chip, but a rigorous assessment...
ORGANISM(S): Homo sapiens 
2008-01-31 | E-GEOD-9842 | biostudies-arrayexpress
GenomicsNext Generation Sequencing Facilitates Quantitative Analysis of effect of knockdown of GATA2 on AR binding sites
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare AR binding activity in LNCaP cells with and without knockdown of GATA2. Methods: LNCaP cells between passage number 32-34 were used for assay. Cells are tr...
ORGANISM(S): Homo sapiens 
2014-01-21 | E-GEOD-52725 | biostudies-arrayexpress
MetabolomicsMirabegron displays anticancer effects by globally browning adipose tissues

Metabolic reprogramming in malignant cells is a hallmark of cancer that relies on augmented glycolytic metabolism to support their growth, invasion and metastasis. However, the impact of global adipose metabolism on tumor growth and the drug development by targeting adipose metabolism remain larg...

2023-11-08 | MTBLS8682 | MetaboLights
TranscriptomicsSystematic evaluation of variability in ChIP-chip experiments using predefined DNA targets
The most widely used method for detecting genome-wide protein-DNA interactions is chromatin immunoprecipitation on tiling microarrays, commonly known as ChIP-chip. Here, we conducted the first objective analysis of tiling array platforms, amplification procedures, and signal detection algorithms in ...
ORGANISM(S): Homo sapiens 
2010-09-30 | E-GEOD-10114 | biostudies-arrayexpress
TranscriptomicsExpression data from early rice endosperm
We used microarrays to detail the global programme of gene expression underlying cellularization and identified distinct classes of regulated genes during this process. Rice endosperm at 2 days after pollination(DAP) was selected for RNA extraction and hybridization on Affymetrix microarrays. We sou...
ORGANISM(S): Oryza sativa 
2015-09-01 | E-GEOD-57615 | biostudies-arrayexpress
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