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TranscriptomicsExpression data measured by microarray of CD4+ T cells from healthy individuals stimulated with anti-CD3/CD28 with or without IFNb or Th17 polarizing cytokines
Variation in individuals' adaptive immune response is believed to influence susceptibility to complex diseases in humans. The genetic basis of such variation is poorly understood. We measured gene expression from resting and activated CD4+ T cells derived from the peripheral blood of healthy individ...
ORGANISM(S): Homo sapiens 
2014-08-28 | E-GEOD-60235 | biostudies-arrayexpress
TranscriptomicsTime course expression measured by microarray of fresh CD4+ response to activation from healthy individuals
Variation in individuals' adaptive immune response is believed to influence susceptibility to complex diseases in humans. The genetic basis of such variation is poorly understood. We measured gene expression from resting and activated CD4+ T cells derived from the peripheral blood of healthy individ...
ORGANISM(S): Homo sapiens 
2014-08-28 | E-GEOD-60234 | biostudies-arrayexpress
TranscriptomicsExpression data measured by custom Nanostring gene set of CD4+ T cells from healthy individuals stimulated with anti-CD3/CD28 with or without IFNb or Th17 polarizing cytokines
Variation in individuals' adaptive immune response is believed to influence susceptibility to complex diseases in humans. The genetic basis of such variation is poorly understood. We measured gene expression from resting and activated CD4+ T cells derived from the peripheral blood of 348 healthy ind...
ORGANISM(S): Homo sapiens 
2014-08-28 | E-GEOD-60341 | biostudies-arrayexpress
UnknownSemaphorin 6D regulates the late phase of CD4+ T cell primary immune responses.
Not available
S-EPMC2529027 | biostudies-literature
MetabolomicsA Generalized Strategy to Kill Leukemic Cells by Targeting the Regulatory Systems Governing Mitochondrial Membrane Potential
Targeting mitochondria emerges as a promising anti-leukemia strategy, yet selective mitochondrial disruption remains challenging. Here, we identified elevated mitochondrial membrane potential (MMP) as a hallmark of leukemic transformation and chemotherapy-resistant cells, prompting screening for MMP...
2025-07-11 | MTBLS12596 | MetaboLights
TranscriptomicsInfection of apple by Apple stem grooving virus leads to extensive alterations in gene expression patterns but no disease symptoms
To understand the molecular basis of viral diseases, transcriptome profiling has been widely used to correlate host gene expression change patterns with disease symptoms during viral infection in many plant hosts. We used infection of apple by Apple stem grooving virus (ASGV), which produces no dise...
ORGANISM(S): Malus domestica 
2014-04-17 | E-GEOD-53825 | biostudies-arrayexpress
UnknownAcquisition of Streptomycin Resistance by Oxidative Stress Induced by Hydrogen Peroxide in Radiation-Resistant Bacterium Deinococcus geothermalis.
Not available
S-EPMC9456066 | biostudies-literature
ProteomicsA Detergent-Free Grinding Sample Preparation Method Dramatically Enhances PELSA for Mapping Integral Membrane Protein-Ligand Interaction
The conventional use of detergent-containing buffers for integral membrane protein (IMP) extraction may disrupt native protein conformations, potentially compromising the performance of ligand target identification. As a result, there is a lack of reliable, unbiased, detergent-free proteomic method...
ORGANISM(S): Homo sapiens (Human) 
2025-10-15 | PXD064146 | Pride
Sample preparation  membrane protein  protein-ligand interaction 
UnknownThe Impact of Matrix Metalloproteinase-11 Polymorphisms on Colorectal Cancer Progression and Clinicopathological Characteristics.
Not available
S-EPMC9317823 | biostudies-literature
UnknownIdentification of novel biomarkers and therapeutic target candidates for stasis-heat symptom pattern of acute intracerebral hemorrhage by quantitative plasma proteomics.
Not available
S-EPMC9924781 | biostudies-literature
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