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TranscriptomicsDirect ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells (RNA-seq)
Aberrant DNA hypermethylation of CpG island (CGI) promoters are associated with transcriptional repression of many tumor suppressor genes and lead to tumor progression in many cancers. Most recently, one research group observed that aberrantly hypermethylated genes in multiple cancers are already re...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43093 | biostudies-arrayexpress
GenomicsDirect ChIP-bisulfite sequencing reveals a role of H3K27me3 mediating aberrant hypermethylation of promoter CpG islands in cancer cells (ChIP-BS)
The model describing that aberrant CpG island (CGI) methylation leads to transcription repression of tumor suppressor genes and thereby is implicated in tumor progression has been established in many cancers. However, recent studies indicated aberrantly hypermethylated genes in multiple cancers are ...
ORGANISM(S): Homo sapiens 
2014-07-01 | E-GEOD-43094 | biostudies-arrayexpress
ProteomicsCanagliflozin ameliorates progestin resistance by suppressing RARβ/CRABP2 signaling in TRβ knockout endometrial cancer cells
THRB-knockout RL95-2 (THRB(-/-)/RL95-2) cells were constructed to investigate progestin resistance mechanisms. Cell proliferation and apoptosis were assessed in RL95-2 and THRB(-/-)/RL95-2 cells treated with canagliflozin (CANA), medroxyprogesterone acetate (MPA), or their combination using CCK-8, E...
ORGANISM(S): Homo Sapiens 
2025-02-07 | PXD060591 |
ProteomicsProteomics analysis of glioma cells and astrocytes
Cell membranes harvested from U251 and primary healthy astrocytes were prepared for LC-MS/MS analysis. After analysis, we could obtain a pool of proteins, which were enriched in the U251 cell membrane sample rather than healthy astrocyte membrane sample.
ORGANISM(S): Homo Sapiens 
2022-01-06 | PXD030760 |
ProteomicsBRD4 regulates the osteogenic differentiation of MSCs
MSCs were lysed in cell lysis buffer for Western blotting and IP (Beyotime, Cat. No. P0013). A Dynabeads™ protein G immunoprecipitation kit (Invitrogen, Cat. No. 10007D) was used for Co-IP according to the manufacturer’s instructions. Dynabeads were resuspended and placed on a magnet to remove the s...
ORGANISM(S): Homo Sapiens 
2022-06-16 | PXD034615 |
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