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ProteomicsDbf4-dependent kinase (DDK) and the Rtt107 scaffold promote Mus81-Mms4 resolvase activation during mitosis
DNA repair by homologous recombination is under stringent cell cycle control. This includes the last step of the reaction, disentanglement of DNA joint molecules (JMs). Previous work has established that JMs resolving nucleases are activated specifically at the onset of mitosis. In case of budding y...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-01-21 | PXD005356 | Pride
Ddk Yeast Dna repair 
UnknownDDK/Hsk1 phosphorylates and targets fission yeast histone deacetylase Hst4 for degradation to stabilize stalled DNA replication forks.
Not available
S-EPMC8565929 | biostudies-literature
ProteomicsDbf4-Dependent Kinase Finetunes INO80 Function at Chromosome Replication Origins
The highly conserved Dbf4-Dependent Kinase (DDK) plays a pivotal role in the nucleus during S phase, where it directly phosphorylates the replicative helicase, the minichromosome maintenance (MCM) complex. This leads to the initiation of chromosome replication. However, aside from the MCM complex, f...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-04-06 | PXD053426 | Pride
Chromosome replication Phosphoproteomics Ino80 Cross-link ms Yeast ddk 
TranscriptomicsOrigin-Dependent DNA Replication in vitro: Insights into DDK and S-CDK function and Replisome Assembly
Initiation of eukaryotic DNA replication requires temporal separation of helicase loading from helicase activation and replisome assembly. Using an in vitro assay for eukaryotic origin-dependent replication initiation, we investigated the control of these events. After helicase loading, we found t...
ORGANISM(S): Saccharomyces cerevisiae 
2011-07-21 | E-GEOD-29646 | biostudies-arrayexpress
UnknownProtein phosphatase 1 recruitment by Rif1 regulates DNA replication origin firing by counteracting DDK activity.
Not available
S-EPMC3989773 | biostudies-literature
UnknownAntagonistic control of DDK binding to licensed replication origins by Mcm2 and Rad53.
Not available
S-EPMC7398698 | biostudies-literature
GenomicsDbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae
Restricting the localization of the centromeric histone H3 variant CENP-A to centromeres is essential to prevent chromosomal instability (CIN). Mislocalization of overexpressed CENP-A contributes to CIN in yeast, fly, and human cells. CENP-A is overexpressed in many cancers. Therefore, defining mech...
ORGANISM(S): Saccharomyces cerevisiae S288C 
2020-04-04 | GSE148068 | GEO
GenomicsDbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae
Dbf4-Dependent Kinase (DDK)-Mediated Proteolysis of CENP-A Prevents Mislocalization of CENP-A in Saccharomyces cerevisiae
PRJNA622995 | ENA
UnknownOrdered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins.
Not available
S-EPMC1589995 | biostudies-literature
UnknownTemporospatial coordination of meiotic DNA replication and recombination via DDK recruitment to replisomes.
Not available
S-EPMC4141489 | biostudies-literature
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