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Proteomicsyeats cells AP-MS for Jhd2 and Tpk2 relative to article Phosphorylation of Jhd2 by the Ras-cAMP- PKA pathway regulates histone modifications and autophagy
This work uncovers a novel and biologically significant mechanism that directly connects nutrient availability to histone modifications and gene transcription. We report that glycolysis promotes histone H3K4 trimethylation (H3K4me3) by activating Tpk2, a catalytic subunit of protein kinase A (PKA...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-29 | PXD030815 | Pride
Yeast jhd2 
GenomicsHistone H3K4 Demethylation is Negatively Regulated by Histone H3 Acetylation in S. cerevisiae
Histone H3 lysine 4 tri-methylation (H3K4me3) is a hallmark of transcription initiation, but how H3K4me3 is demethylated during gene repression is poorly understood. Jhd2, a JmjC domain protein, was recently identified as the major H3K4me3 histone demethylase (HDM) in S. cerevisiae. While JHD2 is ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-11-05 | E-GEOD-41424 | biostudies-arrayexpress
TranscriptomicsReplication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast
Histone modifications affect DNA-templated processes ranging from transcription to genomic replication. In this study, we examine the cell cycle dynamics of the trimethylated form of histone H3 lysine 4 (H3K4me3), a mark of active chromatin that is viewed as â??long-livedâ?? [1], and that is involve...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-24 | E-GEOD-14565 | biostudies-arrayexpress
UnknownH3K4 Methylation Dependent and Independent Chromatin Regulation by JHD2 and SET1 in Budding Yeast.
Not available
S-EPMC5940172 | biostudies-literature
TranscriptomicsTranscriptional regulation by Set1 H3K4 methyltransferase and Jhd2 H3K4 demethylase
Histone H3K4 methylation is connected to gene transcription from yeast to humans, but its mechanistic role in transcription and chromatin dynamics remains poorly understood. Here, we investigated the functions for Set1 and Jhd2, the sole H3K4 methyltransferase and H3K4 demethylase, respectively, in ...
ORGANISM(S): Saccharomyces cerevisiae 
2016-06-15 | E-GEOD-73406 | biostudies-arrayexpress
GenomicsRegulation of chromatin structure by Set1 H3K4 methyltransferase and Jhd2 H3K4 demethylase
Histone H3K4 methylation is connected to gene transcription from yeast to humans, but its mechanistic role in transcription and chromatin dynamics remains poorly understood. Here, we investigated the functions for Set1 and Jhd2, the sole H3K4 methyltransferase and H3K4 demethylase, respectively, in ...
ORGANISM(S): Saccharomyces cerevisiae 
2016-06-15 | E-GEOD-73404 | biostudies-arrayexpress
GenomicsKDM5 Lysine Demethylases Are Involved in Maintenance of 3'UTR Length [ChIP-Seq]
We discovered that the Saccharomyces cerevisiae lysine demethylase, Jhd2 (also known as KDM5), recruits 3'UTR processing machinery and promotes alteration of 3'UTR length in a demethylase-dependent manner. Interaction of Jhd2 with both chromatin and RNA suggests that Jhd2 affects selection of polyad...
ORGANISM(S): Saccharomyces cerevisiae 
2016-03-23 | E-GEOD-67211 | biostudies-arrayexpress
GenomicsRegulation of chromatin structure by Set1 H3K4 methyltransferase and Jhd2 H3K4 demethylase [histone turnover]
Histone H3K4 methylation is connected to gene transcription from yeast to humans, but its mechanistic role in transcription and chromatin dynamics remains poorly understood. Here, we investigated the functions for Set1 and Jhd2, the sole H3K4 methyltransferase and H3K4 demethylase, respectively, in ...
ORGANISM(S): Saccharomyces cerevisiae 
2016-06-15 | E-GEOD-81021 | biostudies-arrayexpress
GenomicsRegulation of chromatin structure by Set1 H3K4 methyltransferase and Jhd2 H3K4 demethylase [ChIP-seq]
Histone H3K4 methylation is connected to gene transcription from yeast to humans, but its mechanistic role in transcription and chromatin dynamics remains poorly understood. Here, we investigated the functions for Set1 and Jhd2, the sole H3K4 methyltransferase and H3K4 demethylase, respectively, in ...
ORGANISM(S): Saccharomyces cerevisiae 
2016-06-15 | E-GEOD-81022 | biostudies-arrayexpress
UnknownCounteracting H3K4 methylation modulators Set1 and Jhd2 co-regulate chromatin dynamics and gene transcription.
Not available
S-EPMC4919544 | biostudies-literature
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