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TranscriptomicsHuman mitochondria hub of small RNAs: Analysis by deep Sequencing
We report here that human mitochondria contain small RNA including microRNA, piRNA, tRNA, rRNA, and RNA repeats. Mitochondria from human cells were purified and RNA isolated. Small RNAs were purified, library generated and analyzed by Illumina Hiseq 2000 system. The sequencing generated 19.5 and 17....
ORGANISM(S): Homo sapiens 
2013-03-05 | E-GEOD-32185 | biostudies-arrayexpress
MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
MetabolomicsCell-based and multi-omics profiling reveal dynamic metabolic repurposing of mitochondria to drive developmental progression of Trypanosoma brucei

Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle since the insect stage utilizes the cost-effective oxidative phosphorylation to generate ATP, while bloodstream cells switch to less energetically efficient aerobic glycolysis. Due to difficulties in a...

2020-08-20 | MTBLS1390 | MetaboLights
TranscriptomicsCommunication between mitochondria and nucleus: defining a retrograde response in fission yeast
Retrograde response was widely studied in budding yeast but the main transcription factors that transmit it (RTG1,2 and 3) are not conserved in other organisms, thus it is interesting to study how communication between mitochondria and nucleus evolved in distantly related fission yeast, and which ar...
ORGANISM(S): Schizosaccharomyces pombe 
2016-11-01 | E-MTAB-4520 | biostudies-arrayexpress
ProteomicsCross-linking mass spectrometry of yeast mitochondria grown on different carbon sources reveal Ndi1, Min8 and Pet9 associated with the electron transport chain
Mitochondria derived from Saccharomyces cerevisiae grown on either a non-fermentable (glycerol) or a fermentable (glucose) carbon source were cross-linked with BS3. Additionally, by using a stable-isotope labelled quantitative cross-linking approach, we were able to quantify differences in protein-p...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-04-27 | PXD017620 | Pride
Carbon source Cross-linking Mass spectrometry Quantitative Yeast Saccharomyces cerevisiae Qxl-ms Xl-ms Mitochondria 
TranscriptomicsTo analyze the effect of loss of mitochondria on the transcriptome of Candida albicans
This set of experiment was done in order to analyze the effect of a dysfunctional mitochondria on C. albicans. The mutant was obtained by deleting the gene FZO1, which is known to be involved in mitochondrial biogenesis in S. cerevisiae. We show that the deletion of FZO1 leads to a change in mitocho...
ORGANISM(S): Candida albicans 
2013-12-05 | E-GEOD-46003 | biostudies-arrayexpress
TranscriptomicsLooking for mitochondrial associated RNA
We investigated the peripheral mitochondrial localization of nuclear-encoded mRNAs (MLR) in various conditions in which translation was inhibited or the mRNA binding protein context altered (Delta puf3). We used cell fractionation protocols together with microarray to assess the distribution of mRNA...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-01 | E-GEOD-9393 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of S. cerevisiae reveaks increasing nadh oxidation reduces overflow metabolism
When the yeast Saccharomyces cerevisiae is subjected to increasing glycolytic fluxes under aerobic conditions, there is a threshold value of the glucose uptake rate at which the metabolism shifts from being purely respiratory to mixed respiratory and fermentative. This shift is characterized by etha...
ORGANISM(S): Saccharomyces cerevisiae 
2008-06-14 | E-GEOD-6277 | biostudies-arrayexpress
ProteomicsDraft of the mitochondrial landscape
The mitochondrial subcompartment proteomes revealed by quantitative MS.
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-11-15 | PXD005541 | Pride
Mitochondria Yeast Subcompartments 
GenomicsDNA copy number, including telomeres and mitochondria, assayed using next-generation sequencing
DNA copy number variations occur within populations and aberrations can cause disease. We sought to develop an improved lab-automatable, cost-efficient, accurate platform to profile DNA copy number. We developed a sequencing-based assay of nuclear, mitochondrial, and telomeric DNA copy number that ...
ORGANISM(S): Homo sapiens 
2010-04-02 | E-GEOD-21159 | biostudies-arrayexpress
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