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TranscriptomicsThe human mitochondrial transcriptome
The human mitochondrial genome comprises a distinct genetic system transcribed as precursor polycistronic transcripts that are subsequently cleaved to generate individual mRNAs, tRNAs and rRNAs. Here we provide a comprehensive analysis of the human mitochondrial transcriptome across multiple cell li...
ORGANISM(S): Homo sapiens 
2011-07-20 | E-GEOD-30772 | biostudies-arrayexpress
TranscriptomicsHeLa cell mitochondrial microRNAs
MicroRNAs (miRNAs) are small non-coding RNAs that associate with Argonaute 2 protein to regulate gene expression at the post-transcriptional level in the cytoplasm. However, recent studies have reported that some miRNAs localize to and function in other cellular compartments. Mitochondria harbour th...
ORGANISM(S): Homo sapiens 
2011-10-05 | E-GEOD-24761 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human 293T cell line mitochondrial small RNA transcriptome
This study aimed to determine whether human nuclear-encoded tRNAs can enter mitochondria and to assess their potential involvement in mitochondrial protein translation. We isolated cytoplasmic fractions, intact mitochondria, and mitoplasts from human HEK293T cells and performed small RNA sequencing ...
ORGANISM(S): Homo sapiens 
2026-08-27 | E-MTAB-15948 | biostudies-arrayexpress
TranscriptomicsSmall RNA sequencing of mitochondria and whole fraction of human umbilical vein endothelial cells treated with hydrogen peroxide
Numerous miRNAs have been found in mitochondria and these mitochondrial miRNAs have been shown important roles in many physiological and pathophysiological processes. However, the dynamic changes of miRNA distribution in mitochondria in the endothelial oxidative injury are still unclear. Therefore, ...
ORGANISM(S): Homo sapiens 
2023-10-31 | E-MTAB-9851 | biostudies-arrayexpress
TranscriptomicsProteomic and transcriptomic analyses of Dhh1 complexes reveals mitochondrial RNP complex association with yeast P-bodies
P-bodies (PB) are cytoplasmic RNP complexes that aggregate into foci when cells are exposed to stress. While the core components and stress response of PB and related RNP granules are conserved, it remains unclear how and why cells assemble mRNP complexes into granule foci during stress. We use mas...
ORGANISM(S): Saccharomyces cerevisiae 
2015-09-16 | E-GEOD-65989 | biostudies-arrayexpress
TranscriptomicsUsing mitoribosomal profiling to investigate human mitochondrial translation
Human 143B.206 Rho+ cells (depleted mitochondrial DNA) and cytoplasts (derived from mitochondrial patient fibroblast containing C1624T mutation in mitochondrial tRNAVal ) were previously used to generated transmitochondrial cybrid lines. Hek293T cells,143B cells and cybrid cells were cultured in DME...
ORGANISM(S): Homo sapiens 
2017-12-01 | E-MTAB-6284 | biostudies-arrayexpress
TranscriptomicsAntisense Transcripts Impede Uridylation-induced Exonucleolytic Degradation to Generate Guide RNAs
Small non-coding RNA biogenesis typically involves cleavage of structured precursors by RNase III-like endonucleases. However, guide RNAs that direct U-insertion/deletion mRNA editing in mitochondria of trypanosomes maintain 5′ triphosphate characteristic of transcription start site and possess U-...
ORGANISM(S): Trypanosoma brucei 
2016-02-08 | E-GEOD-71292 | biostudies-arrayexpress
ProteomicsDefinition of a high-confidence mitochondrial proteome at quantitative scale_subcellular profiling
Mitochondria perform central functions in cellular bioenergetics, metabolism and signaling and their malfunction has been linked to numerous diseases. The available studies cover only part of the mitochondrial proteome and a separation of core mitochondrial proteins from associated fractions has not...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-06-29 | PXD006128 | Pride
Organellar proteomics Saccharomyces cerevisiae 
MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
ProteomicsOXPHOS deficiency activates global adaptations to maintain mitochondrial membrane potential
Reduction of mitochondrial membrane potential is a hallmark of mitochondrial dysfunction. It activates adaptive responses in organisms from yeast to human to rewire metabolism, remove depolarized mitochondria, and degrade unimported precursor proteins. It remains unclear how cells maintain mitochond...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-01-19 | PXD022805 | Pride
Q exactive mass spectrometer Ltq orbitrap velos Saccharomyces cerevisiae 
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