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MetabolomicsDeep functional analysis of synII, a 770 kb synthetic yeast chromosome
Here we report the design, construction and characterization of a 770 Kb synthetic yeast chromosome II (synII). With the UPLC-MS method, we demonstrated synII maintains a nearly wild-type phenotype and fitness despite hundreds of designer editing to it. Our phenomics, transcriptomics, proteomics dat...
2016-10-13 | MTBLS296 | MetaboLights
MetabolomicsInteraction of Genetic Variants Activates Latent Metabolic Pathways in Yeast

Genetic interactions are fundamental to the architecture of complex traits, yet the molecular mechanisms by which variant combinations influence cellular pathways remain poorly understood. Here, we answer the question of whether interactions between genetic variants can activate unique pathways a...

2025-07-22 | MTBLS12761 | MetaboLights
MetabolomicsRedox proteomics reveal a role for peroxiredoxinylation in stress protection.

The redox state of proteins is essential for their function and guarantees cell fitness. Peroxiredoxins protect cells against oxidative stress, maintain redox homeostasis, act as chaperones, and transmit hydrogen peroxide signals to redox regulators. Despite the profound structural and functional...

2025-07-17 | MTBLS11979 | MetaboLights
MetabolomicsGrowth control of the eukaryote cell: a systems biology study in yeast
Metabolic control analysis is being exploited in a systems biology study of the eukaryotic cell. Using chemostat culture, we have measured the impact of changes in flux (growth rate) on the transcriptome, proteome, endometabolome and exometabolome of the yeast Saccharomyces cerevisiae. Each function...
2012-04-19 | MTBLS8 | MetaboLights
MetabolomicsModel-guided development of evolutionarily stable yeast chassis for dicarboxylic acids production

Chassis strain suitable for producing multiple compounds is a central concept in synthetic biology. Design of a chassis using computational, first-principle, models is particularly attractive due to the predictability and control it offers, including against phenotype reversal due to adaptive mut...

2021-07-19 | MTBLS2007 | MetaboLights
ProteomicsSystem-wide perturbation analysis with nearly complete coverage of the yeast proteome by single-shot ultra HPLC runs on a bench top Orbitrap
Yeast remains an important model for systems biology and for evaluating proteomics strategies. In-depth shotgun proteomics studies have reached nearly comprehensive coverage, and rapid, targeted approaches have been developed for this organism. Recently, we demonstrated that single LC-MS/MS analysis...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2021-07-22 | PXD000409 | Pride
Yeast Q exactive 
ProteomicsYeast inter-species comparative proteomics
Different yeast species in distinct clades within Saccharomycetaceae family are interesting model organisms for inter-species comparative proteomics, in regard to different metabolic properties and genomic architectures. The aim in this analysis is revealing conserved and diverse expression profile ...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2015-11-16 | PXD001865 | Pride
Yeast Comparative proteomics Saccharomycetaceae family 
ProteomicsYeast inter-species comparative proteomics
Different yeast species in distinct clades within Saccharomycetaceae family are interesting model organisms for inter-species comparative proteomics, in regard to different metabolic properties and genomic architectures. The aim in this analysis is revealing conserved and diverse expression profile ...
ORGANISM(S): Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) 
2015-11-17 | PXD001868 | Pride
Yeast Comparative proteomics Saccharomycetaceae family 
ProteomicsPhosphosites of the yeast centrosome component Spc110 contribute to mitotic exit
Spc110 is an essential component of the spindle pole body (SPB), the yeast equivalent of the centrosome, that recruits the gamma-tubulin complex to the nuclear side of SPB to form the mitotic spindle. Here we identify two phosphosites (S11 and S36) in old (from maternal origin) Spc110. Yeast expres...
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast) 
2023-04-03 | PXD033085 | JPOST Repository
ProteomicsYeast inter-species comparative proteomics
Different yeast species in distinct clades within Saccharomycetaceae family are interesting model organisms for inter-species comparative proteomics, in regard to different metabolic properties and genomic architectures. The aim in this analysis is revealing conserved and diverse expression profile ...
ORGANISM(S): Lachancea waltii NCYC 2644 
2015-11-17 | PXD001867 | Pride
Yeast Comparative proteomics Saccharomycetaceae family 
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