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GenomicsRepression of the soma-specific transcriptome by Polycomb-repressive complex 2 promotes male germ cell development
Polycomb-repressive complex 2 (PRC2) catalyzes the methylation of histone H3 Lys27 (H3K27) and functions as a critical epigenetic regulator of both stem cell pluripotency and somatic differentiation, but its role in male germ cell development is unknown. Using conditional mutagenesis to remove the c...
ORGANISM(S): Mus musculus 
2014-10-01 | E-GEOD-61902 | biostudies-arrayexpress
TranscriptomicsfourSig: A Method for Determining Chromosomal Interactions in 4C-Seq Data
The ability to correlate chromosome conformation and gene expression gives a great deal of information regarding the strategies used by a cell to properly regulate gene activity. 4C-seq is a relatively new and increasingly popular technology where the set of genomic interactions generated by a singl...
ORGANISM(S): Mus musculus 
2014-02-22 | E-GEOD-50907 | biostudies-arrayexpress
TranscriptomicsEscape from X chromosome inactivation occurs within topologically associated domains
The spatial proximity between regulatory elements and their target genes has a profound affect on gene expression. X Chromosome Inactivation (XCI) is an epigenetic process by which an entire chromosome is rendered, for the most part, transcriptionally silent. A few genes are known to escape XCI and ...
ORGANISM(S): Mus musculus 
2014-03-26 | E-GEOD-49111 | biostudies-arrayexpress
GenomicsKDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development
H3K27me3 represses developmental genes at initial embryonic stages. The KDM6 family, comprised of UTX and JMJD3, are the only known proteins that demethylate H3K27me3 and they are hypothesized to catalyze the rapid removal of repressive chromatin in early mammalian development. However, we report th...
ORGANISM(S): Mus musculus 
2014-06-12 | E-GEOD-58391 | biostudies-arrayexpress
UnknownIn vivo [64Cu]CuCl2 PET imaging reveals activity of Dextran-Catechin on tumor copper homeostasis.
Not available
S-EPMC6276294 | biostudies-literature
UnknownEvolution of antibody immunity to SARS-CoV-2.
Not available
S-EPMC8221082 | biostudies-literature
UnknownTherapeutic Anticoagulation with Heparin in Noncritically Ill Patients with Covid-19.
Not available
S-EPMC8362594 | biostudies-literature
UnknownMetformin for patients with metastatic prostate cancer starting androgen deprivation therapy: a randomised phase 3 trial of the STAMPEDE platform protocol.
Not available
S-EPMC12303861 | biostudies-literature
UnknownWound irrigation does not affect health-related quality of life after open fractures: results of a randomized controlled trial.
Not available
S-EPMC6413805 | biostudies-literature
UnknownAre large clinical trials in orthopaedic trauma justified?
Not available
S-EPMC5909275 | biostudies-literature
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