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TranscriptomicsSingle-cell immune repertoire sequencing of bone marrow plasma cells following infection and immunizations
We performed single-cell transcriptome and antibody repertoire sequencing of bone marrow plasma cells following protein (OVA and TNFR2) immunizations or infection with high dose LCMV clone 13.
ORGANISM(S): Mus musculus 
2021-12-01 | E-MTAB-11096 | biostudies-arrayexpress
TranscriptomicsInflationary T cell receptor sequencing following MCMV infection in Tcf1 transgenic mice
Inflationary T cells were isolated from various organs in Tcf1-GFP mice following MCMV infection. TCRbeta sequencing was performed using Illumina MiSeq 2x300 platform. Peripheral tissue samples correspond to either Tcf1-high or Tcf1-low from spleen/lung/lymph nodes. Blood samples correspond to bulk ...
ORGANISM(S): Mus musculus 
2020-02-25 | E-MTAB-8711 | biostudies-arrayexpress
TranscriptomicsGene expression comparing Memory Bystander T cell Function with and without LCMV infection
We compared the effect of chronic virus infection on the gene expression of memory bystander T cells.
ORGANISM(S): Mus musculus 
2019-01-25 | E-MTAB-7594 | biostudies-arrayexpress
TranscriptomicsAntibody repertoire sequencing of blood and bone marrow plasma cell compartments following lymphocytic choriomeningitis virus infection
Antibody repertoire sequencing of blood and bone marrow plasma cell compartments following lymphocytic choriomeningitis virus infection. Heavy chain repertoires of 5 uninfected mice, 5 acutely infected mice and 5 chronically infected mice were longitudinally sequenced over 80 days. All samples are ...
ORGANISM(S): Mus musculus 
2020-01-16 | E-MTAB-8585 | biostudies-arrayexpress
TranscriptomicsA single-cell atlas of lymphocyte adaptive immune repertoires and transcriptomes reveals age-related differences in convalescent COVID-19 patients
We utilize single-cell sequencing (scSeq) of lymphocyte immune repertoires and transcriptomes to quantitatively profile the adaptive immune response in COVID-19 patients of varying age. Our scSeq analysis defines the adaptive immune repertoire and transcriptome in convalescent COVID-19 patients and ...
ORGANISM(S): Homo sapiens 
2021-03-20 | E-MTAB-10169 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of conventional and regulatory CD4+ T cells of healthy human donors
Transcriptional profiles of conventional and regulatory CD4+ T cells were compared in healthy individuals (caucasian males).
ORGANISM(S): Homo sapiens 
2020-03-04 | E-MTAB-8819 | biostudies-arrayexpress
TranscriptomicsRegulatory and effector T cells in Lymphocytic choriomeningitis virus WE infection
In this study, we determined the signature of CD4+Foxp3- effector T cells and CD4+Foxp3+ Treg cells in naive animals and following LCMV WE infection. In addition, transcriptional signatures were determined in CXCR3+ CD4+Foxp3+ Treg cells arising in Th1 settings following LCMV infection.
ORGANISM(S): Mus musculus 
2020-03-11 | E-MTAB-8861 | biostudies-arrayexpress
TranscriptomicsscRNA- and TCR-Seq of mouse T cells from WT and TIGIT KO mice at steady state and upon LCMV infection
The experimental setup is aimed at understanding the function of the co-inhibitory receptor TIGIT in T cells. We compared sorted T cells (CD8+ T cells, CD4+Foxp3- T cells, CD4+Foxp3+ Tregs) from WT and TIGIT KO mice at steady state (naive mice) and following LCMV infection (day 10, LCMV clone 13). C...
ORGANISM(S): Mus musculus 
2025-09-14 | E-MTAB-14959 | biostudies-arrayexpress
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