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We generated maternal and paternal mouse models with Yap1-deletion, and elucidated the function of maternal YAP in zygotic genome activation. RNA sequencing with 2 WT oocyte samples at GV stage, 2 YAP-/- oocyte samples at GV stage, 1 WT embryo samples at 4cell stage, 1 YAP-/- embryo samples at at 4-...
ORGANISM(S): Mus musculus 
Liver undergoes both size increase and differentiation during postnatal period, which in mice is approximately first 30 days. The mechanisms of simultaneous postnatal liver cell proliferation and maturation are not clear. In these experiments, role of yes associated protein (Yap), the downstream eff...
ORGANISM(S): Mus musculus 
Human Yes Associated Protein (hYAP) expressing mouse liver
Progesterone, via yes-associated protein (YAP), promotes cardiomyocyte proliferation and cardiac repair
Genomics
Yes-associated protein in hepatocytes protects against early alcohol-associated liver disease
Genomics
Matrix stiffness epigenetically regulates the oncogenic activation of the Yes-associated protein in gastric cancer
Doxycycline-inducible YAP1 S127A-driven rhabdomyosarcoma (RMS) tumors, control skeletal muscle and regressed tumors following YAP1 normalization by doxycycline withdrawal were compared to determine the YAP1-regulated gene expression profile relevant to RMS formation. To characterize the role of YAP1...
ORGANISM(S): Mus musculus 
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