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ProteomicsRepression of PRMT5-mediated dimethylation stabilizes vimentin and promotes metastasis in MTAP-loss lung cancer
Abstract The aggressive nature and poor prognosis of lung cancer led us to explore the mechanisms driving disease progression. Utilizing our invasive cell-based model, we identified methylthioadenosine phosphorylase (MTAP) and confirmed its suppressive effects on tumorigenesis and metastasis, and pa...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD031192 | Pride
Human Dimethylation Lung cancer 
UnknownFolate Deficiency Triggered Apoptosis of Synoviocytes: Role of Overproduction of Reactive Oxygen Species Generated via NADPH Oxidase/Mitochondrial Complex II and Calcium Perturbation.
Not available
S-EPMC4714898 | biostudies-literature
UnknownA Phase 3 Study of Pembrolizumab versus Placebo for Previously Treated Patients from Asia with Hepatocellular Carcinoma: Health-Related Quality of Life Analysis from KEYNOTE-394.
Not available
S-EPMC11305669 | biostudies-literature
UnknownMechanical stretch induces hair regeneration through the alternative activation of macrophages.
Not available
S-EPMC6447615 | biostudies-literature
UnknownA machine-learning-enabled smart neckband for monitoring dietary intake.
Not available
S-EPMC11075646 | biostudies-literature
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
ProteomicsThe bipolar disorder GWAS risk gene NEK4 modulates circadian fluctuations of murine emotional behaviors and synaptogenesis
Through integrative analyses of GWAS summary statistics, population genetic data and expression quantitative trait loci (eQTL) annotations, we found that elevated NEK4 expression in hippocampus was causatively linked to the risk of BD. To examine the biological impact of this gene, we generated NEK4...
ORGANISM(S): Mus <genus> 
2024-05-11 | PXD052190 |
UnknownClinical impact of pharmacogenetic risk variants in a large chinese cohort.
Not available
S-EPMC12241563 | biostudies-literature
UnknownManagement of severe sepsis in patients admitted to Asian intensive care units: prospective cohort study.
Not available
S-EPMC3113333 | biostudies-literature
UnknownPrognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings.
Not available
S-EPMC10804657 | biostudies-literature
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