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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
GenomicsDNA methylomes of the fire ant Solenopsis invicta.
We used whole bodies of four different adult fire ant morphs (alate queens, workers, haploid males, and diploid males) from a single polygyne colony to generate single-base resolution DNA methylation maps. DNA was extracted from whole bodies of individual males, individual queens, and pooled workers...
ORGANISM(S): Solenopsis invicta 
2013-03-27 | E-GEOD-39959 | biostudies-arrayexpress
TranscriptomicsMicroRNA-203 represses selection and expansion of oncogenic HRas transformed tumor initiating cells [seq]
In many mouse models of skin cancer, only a few tumors typically form although many cells competent for tumorigenesis receive the same oncogenic mutations. These observations suggest a selection process for defining tumor initiating cells. Here we use quantitative mRNA- and miR-Seq to determine the ...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-66054 | biostudies-arrayexpress
ProteomicsAkt2 partners L6 myoblasts - Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts
Insulin resistance and Type 2 diabetes are marked by an aberrant response in the insulin signaling network. The phosphoinositide-dependent serine/threonine kinase, Akt2, plays a key role in insulin signaling and glucose uptake, most notably within skeletal muscle. Protein-protein interaction regul...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-30 | PXD002557 | Pride
Akt2 Hplc-esi-ms/ms Rock2 
Proteomicsyagpm2_1
enrichment for specialized purple membrane proteins, cell culture #2 Goo et al., unpublished data.
ORGANISM(S): Halobacterium Nrc-1 (halobacterium) 
2012-12-31 | PAe000256 | PeptideAtlas
UnknownInsights into archaeal evolution and symbiosis from the genomes of a nanoarchaeon and its inferred crenarchaeal host from Obsidian Pool, Yellowstone National Park.
Not available
S-EPMC3655853 | biostudies-literature
MetabolomicsSmall intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an o...
2019-04-30 | MTBLS876 | MetaboLights
UnknownMUC1 Expressions and Its Prognostic Values in US Gastric Cancer Patients.
Not available
S-EPMC9954699 | biostudies-literature
ProteomicsYAGmem812
enrichment for membrane proteins; 800-1200 m/z; Goo et al., 2003, Mol Cell Proteomics 2(8):509
ORGANISM(S): Halobacterium Nrc-1 (halobacterium) 
2006-12-31 | PAe000179 | PeptideAtlas
Proteomicsyagsn1_712rpt
replicate enrichment for soluble proteins; 700-1200 m/z; Goo et al., 2003, Mol Cell Proteomics 2(8):508
ORGANISM(S): Halobacterium Nrc-1 (halobacterium) 
2006-12-31 | PAe000210 | PeptideAtlas
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