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ProteomicsA reference dataset of O-GlcNAc proteins in quadriceps skeletal muscle from mice
A key nutrient sensing process in all animal tissues is the dynamic attachment of O-linked N-acetylglucosamine (O-GlcNAc). Determining the targets and roles of O-GlcNAc glycoproteins has the potential to reveal insights into healthy and diseased metabolic states. In cell studies, thousands of protei...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-21 | PXD060554 | Pride
Glycoproteomics Skeletal muscle O-glcnac Mouse quadriceps Tissue atlas 
ProteomicsQuantitative Proteomics Reveals Transforming growth factor beta Axis Induced by Resveratrol and Hesperetin Coformulation in Endothelial Cells
The endothelium is the frontline target of multiple metabolic stressors and pharmacological agents. As a consequence, endothelial cells (ECs) display highly dynamic and diverse proteome profiles. We describe here the culture of human aortic ECs from healthy and type 2 diabetic donors, the treatment ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD036094 | Pride
Endothelial cells  type 2 diabetes  trans-resveratrol  proteomics  transforming growth factor-beta 
ProteomicsAkt2 partners L6 myoblasts - Novel Endogenous, Insulin-Stimulated Akt2 Protein Interaction Partners in L6 Myoblasts
Insulin resistance and Type 2 diabetes are marked by an aberrant response in the insulin signaling network. The phosphoinositide-dependent serine/threonine kinase, Akt2, plays a key role in insulin signaling and glucose uptake, most notably within skeletal muscle. Protein-protein interaction regul...
ORGANISM(S): Rattus norvegicus (Rat) 
2015-09-30 | PXD002557 | Pride
Akt2 Hplc-esi-ms/ms Rock2 
ProteomicsActive kinome in human skeletal muscle insulin resistance
Obesity-related insulin resistance (OIR) is one of the main contributors to type 2 diabetes and other metabolic diseases. Protein kinases are implicated in key signaling steps including insulin signaling and glucose metabolism. Molecular mechanisms underlying OIR involving global active kinases rema...
ORGANISM(S): Homo sapiens (Human) 
2020-01-23 | PXD011909 | Pride
Quantitative proteomics Protein kinase Human skeletal muscle Insulin resistance Active kinome 
ProteomicsQuantitative Proteomics Reveals Transforming growth factor beta Axis Induced by Resveratrol and Hesperetin Coformulation in Endothelial Cells
The endothelium is the frontline target of multiple metabolic stressors and pharmacological agents. As a consequence, endothelial cells (ECs) display highly dynamic and diverse proteome profiles. We describe here the culture of human aortic ECs from healthy and type 2 diabetic donors, the treatment ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2025-06-27 | MSV000098345 | MassIVE
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