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ProteomicsYildirim 4398 Nup153 Interactome
Identify Nup153 interacting proteins in Co-IP coupled with LC-MS/MS
ORGANISM(S): Homo sapiens (Human) 
2021-03-10 | PXD015441 | Pride
Nup153 interaction 
GenomicsX-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription
Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X-inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that X-autosome equalization occurs by upregulation of Xa (active X). To investigate t...
ORGANISM(S): Mus musculus 
2012-01-06 | E-GEOD-33823 | biostudies-arrayexpress
GenomicsSpreading of X-chromosome inactivation via a hierarchy of defined Polycomb stations
Binding of Polycomb repressive complex 2 (PRC2) and chromatin composition of the inactive X (Xi) before, during and after X chromosome inactivation reveal that spreading is driven by a combination of Xi-specific strong and moderate Ezh2 sites. Sequence context of these sites shows a moderate enrichm...
ORGANISM(S): Mus musculus 
2012-11-01 | E-GEOD-36905 | biostudies-arrayexpress
TranscriptomicsXist RNA is a potent suppressor of hematologic cancer in mice.
X-chromosome aneuploidies have long been associated with human cancers, but causality has not been established. In mammals, X-chromosome inactivation (XCI) is triggered by Xist RNA to equalize gene expression between the sexes. Here we delete Xist in the blood compartment of mice and demonstrate tha...
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-43961 | biostudies-arrayexpress
MetabolomicsEarly postnatal metabolic profile in neonates with different birth weight status: A pilot study

INTRODUCTION: Restricted or enhanced intrauterine growth is associated with elevated risks of early and late metabolic problems in humans. Metabolomics based on amino acid and carnitine/acylcarnitine profile may have a role in fetal and early postnatal energy metabolism. In this ...

2021-04-28 | MTBLS2376 | MetaboLights
TranscriptomicsAllelic imbalance is a prevalent and tissue-specific feature of the mouse transcriptome
We perform a systematic classification of allelic imbalance in mouse hybrids derived from reciprocal crosses of divergent strains. We observe that deviation from balanced biallelic expression is common, occurring in ~20% of the mouse transcriptome. Allelic imbalance attributed to genotype is by far ...
ORGANISM(S): Mus musculus 
2015-05-28 | E-GEOD-58524 | biostudies-arrayexpress
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