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TranscriptomicsPLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and glioma
A hallmark feature of glioblastoma (GBM) cells is its strong self-renewal potential and immature differentiation state -- stem cell-like properties which may contribute to the plasticity and intense therapeutic resistance of GBM. The molecular basis of the immature differentiation profile remains a...
ORGANISM(S): Mus musculus 
2010-06-23 | E-GEOD-21143 | biostudies-arrayexpress
TranscriptomicsFoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis
FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis expression profile between six independant neural stem cell lines (three FoxO null and three wild type) were compared
ORGANISM(S): Mus musculus 
2009-12-31 | E-GEOD-18308 | biostudies-arrayexpress
TranscriptomicsKras is required for pancreatic tumor maintenance through regulation of hexosamine biosynthesis and the non-oxidative pentose phosphate pathway
The maintenance of advanced malignancies relies on continued activity of driver oncogenes, although their rate-limiting role is highly context-dependent with respect to tumor types and associated genetic alterations. Oncogenic Kras mutation is the signature event in human pancreatic ductal adenocar...
ORGANISM(S): Mus musculus 
2012-04-29 | E-GEOD-32277 | biostudies-arrayexpress
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