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GenomicsThe Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation
The Mediator complex functions as a control center orchestrating diverse signalings, gene activities, and biological processes. However, how Mediator subunits determine distinct cell fates remains to be fully elucidated. Here, we show that Mediator MED23 controls the cell fate preference that direct...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-40369 | biostudies-arrayexpress
MetabolomicsTranscriptomic and metabolomic analyses reveal the differential accumulation of phenylpropanoids and terpenoids in hemp autotetraploid and its diploid progenitor

Background

Cannabis sativa, a dioecious plant that has been cultivated worldwide for thousands of years, is known for its secondary metabolites, especially cannabinoids, which possess several medicinal effects. In this study, we investigated the autopolyploidization effects on the biosynthes...
2023-09-21 | MTBLS6032 | MetaboLights
ProteomicsIntegrated proteomics and transcriptomics profiling reveals distinct aspects of kidney stone related genes in calculi rats
We conducted a calculi rat model, applied for an integrated proteomic and transcriptomic analysis to characterize the distinct gene expression profiles in calculi oxalate stone formation and its related kidney injury. Six distinct gene clusters were identified according to the consistency of transcr...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-05-10 | PXD039169 | Pride
Calcium oxalate  kidney stone  proteomics  transcriptomics  urolithiasis 
TranscriptomicsAlkaline-stress response in Glycine soja leaf identifies specific transcription factors and ABA-mediated signaling factors
Transcriptome of Glycine soja leaf tissue during a detailed time course formed a foundation for examining transcriptional processes during NaHCO(3) stress treatment. Of a total of 2,310 detected differentially expressed genes, 1,664 genes were upregulated and 1,704 genes were downregulated at variou...
ORGANISM(S): Glycine soja 
2010-10-13 | E-GEOD-20323 | biostudies-arrayexpress
UnknownTherapeutic potential of targeting the IRF2/POSTN/Notch1 axis in nucleus pulposus cells for intervertebral disc degeneration.
Not available
S-EPMC11755837 | biostudies-literature
ProteomicsCross-link assisted spatial proteomics to map sub-organelle proteomes and membrane protein topology
The specific functions of cellular organelles and sub-compartments depend on their protein content, which can be characterized by spatial proteomics approaches. However, many spatial proteomics methods are limited in their ability to resolve organellar sub-compartments, profile multiple sub-compartm...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-02-21 | PXD032132 | Pride
Synaptic vesicles Xl-ms Mitochondria Spatial proteomics 
UnknownGenome-Wide Identification and Analysis of MKK and MAPK Gene Families in Brassica Species and Response to Stress in Brassica napus.
Not available
S-EPMC7827818 | biostudies-literature
UnknownComparative Transcriptome Profiling Reveals Changes of microRNAs Response to Exercise in Rats with Neuropathic Pain.
Not available
S-EPMC8356008 | biostudies-literature
TranscriptomicsExpression data from embryonic stem cells differentiation
Pluripotency-associated transcription factor Foxd3 is required for maintaining pluripotent cells. However, the molecular mechanisms underlying its function are largely unknown. Here, we report that Foxd3 maintains the ESC identity through counteracting differentiation induction of Calcienurin-NFAT s...
ORGANISM(S): Mus musculus 
2014-08-18 | E-GEOD-58960 | biostudies-arrayexpress
UnknownCombination of Enzastaurin and Ibrutinib synergistically induces anti-tumor effects in diffuse large B cell lymphoma.
Not available
S-EPMC6379963 | biostudies-literature
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