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TranscriptomicsRole of Eif4g3 and Deaf1 in Lymph node
This SuperSeries is composed of the following subset Series: GSE29152: Lymph node stromal cells: Control siRNA treated vs. Eif4g3 siRNA treated GSE29153: Differential gene expression in the Pancreatic lymph node of Deaf1 knockout mice vs. wild type littermate controls Refer to individual Series
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-29167 | biostudies-arrayexpress
TranscriptomicsGene expression in the pancreatic lymph nodes (PLN) of hyperglycemic 16-week-old Non-Obese Diabetic (NOD) mice compared to expression the PLN of euglycemic 16-week-old NOD mice.
These experiments were performed to identify differentially expressed genes in the pancreatic lymph nodes of hyperglycemic NOD mice with high levels of destructive insulitis compared to euglycemic mice with lower levels of insulitis. The pancreatic lymph nodes of 16-week-old hyperglycemic and euglyc...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-57237 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in the Pancreatic lymph node of Deaf1 knockout mice vs. wild type littermate controls
Gene expression in the the pancreatic lymph node of 4, 12, and 30 week old Deaf1-knockout (KO) mice compared to BALB/c littermate controls. Gene expression was measured in the pancreatic lymph nodes of 4 wk old Deaf1 KO mice (2 replicates), 12 wk old Deaf1-KO mice (3 replicates), and 30 wk old Deaf1...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-29153 | biostudies-arrayexpress
TranscriptomicsGene expression in the islets of 12 wk old Non-Obese Diabetic (NOD) mice and healthy control NOD.B10 mice
Gene expression in the islets of NOD and NOD.B10 mice at 12 weeks of age, prior to the onset of destructive insulitis. The pancreata of NOD and NOD.B10 mice (n=6) were frozen and islets were isolated by laser capture microdissection. Cryosections (8 M-NM-
ORGANISM(S): Mus musculus 
2013-04-10 | E-GEOD-45897 | biostudies-arrayexpress
TranscriptomicsGene expression in the isolated islets of 10 day old, 4 wk old, 12 wk old, and 20 wk old Non-Obese Diabetic (NOD) mice compared to healthy age matched control NOD.B10 mice
Gene expression in the islets of diseased NOD mice compared to congenic healthy NOD.B10 mice at various ages, during the progression of NOD disease. Islets were isolated from individual NOD and NOD.B10 mice by collagenase digestion. RNA was extracted using Trizol, combined with the RNeasy micro kit ...
ORGANISM(S): Mus musculus 
2013-11-28 | E-GEOD-52815 | biostudies-arrayexpress
TranscriptomicsLymph node stromal cells: Control siRNA treated vs. Eif4g3 siRNA treated
Gene expression in the top, light and heavy polysome fractions of Eif4g3 siRNA treated lymph node stromal cells (LNSCs) compared to control-sIRNA treated samples This study was performed to examine whether the expression of certain genes in LNSCs is regulated by the translation factor, eukaryotic tr...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-29152 | biostudies-arrayexpress
TranscriptomicsLymph node stromal cells: Control siRNA treated vs. Eif4g3 siRNA treated - Total RNA and Heavy polysome fraction
Gene expression in the total RNA and heavy polysome fractions of Eif4g3 siRNA treated lymph node stromal cells (LNSCs) compared to control-sIRNA treated samples The objective of this study was to identify genes whose translation are reduced after silencing Eif4g3 (the gene which encodes the translat...
ORGANISM(S): Mus musculus 
2012-07-19 | E-GEOD-39408 | biostudies-arrayexpress
TranscriptomicsGene expression in the pancreas of healthy control, auto-antibody positive, and type 1 diabetic subjects
These experiments were performed to identify differentially expressed genes in the pancreas of healthy humans, auto-antibody positive and type 1 diabetic patients. All samples were obtained from the network of pancreatic organ donors with diabetes (nPOD). ID numbers are specified. Patient informat...
ORGANISM(S): Homo sapiens 
2015-11-01 | E-GEOD-72492 | biostudies-arrayexpress
TranscriptomicsGene expression in the pancreatic lymph node of Deaf1 knock out mice vs. BALB/c controls
A microarray study performed in the pancreatic lymph nodes of Deaf1 knock-out and BALB/c control mice to identify genes that are regulated by the transcriptional regulator Deaf1. These experiments constitute a portion of the study described below: Abstract: Type 1diabetes (T1D) can result from a b...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-13163 | biostudies-arrayexpress
TranscriptomicsGenome-Wide Gene Expression Profiles in the Pancreatic Lymph Nodes of non-obese diabetic (NOD) mice
Type 1 diabetes (T1D) is a polygenic autoimmune disorder caused by autoreactive T cells that recognize pancreatic islet antigens and subsequently destroy insulin-producing β-cells. Pancreatic lymph nodes (PLN) are an essential site for the development of T1D, where tolerance to pancreatic self-antig...
ORGANISM(S): Mus musculus 
2015-03-09 | E-GEOD-66658 | biostudies-arrayexpress
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