Gene expression in the pancreatic lymph node of Deaf1 knock out mice vs. BALB/c controls

ABSTRACT: A microarray study performed in the pancreatic lymph nodes of Deaf1 knock-out and BALB/c control mice to identify genes that are regulated by the transcriptional regulator Deaf1. These experiments constitute a portion of the study described below: Abstract: Type 1diabetes (T1D) can result from a breakdown in peripheral tolerance which is controlled by peripheral tissue antigen (PTA) expression in lymph nodes. Here, we identified a transcriptional regulator, deformed epidermal autoregulatory factor 1 (Deaf1), which regulates the expression of various PTAs in the pancreatic lymph node (PLN). We found, by microarray, that Deaf1 controls the expression of ~600 genes in the PLN. In the non-obese diabetic (NOD) mouse model of T1D, we identified a wild-type form of Deaf1 (DF1) and a truncated

ORGANISM(S): Mus musculus

SUBMITTER: Rémi Creusot 

PROVIDER: E-GEOD-13163 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress