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ProteomicsChanges in proteome upon mTOR activation
mTOR activation has been known to affect protein synthesis. To identify molecular signatures in transcriptome that could enhance protein synthesis, RNA-seq and quantitative proteomics studies were conducted using WT and TSC1 null MEFs. In this study, we found that the activation of mTOR leads to gen...
ORGANISM(S): Mus musculus (Mouse) 
2015-06-16 | PXD002006 | Pride
3'utr shortening Ubiquitin-mediated proteolysis Alternative polyadenylation Mtor 
TranscriptomicsGenome-wide analysis of snRNAs bound to Gemin5 upon protein synthesis inhibition
Here, we report the genome-wide analysis of snRNAs that are bound to Gemin5 upon protein synthesis inhibition. Upon protein synthesis inhibition, the SMN complex that has a crucial role in the biogenesis of snRNPs dissociates into its subunits, leaving Gemin5 alone. The existence of these subunits w...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-20751 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling by array of miRNAs regulated by Ars2 and DGCR8
siRNAs were used to deplete either Ars2 or DGCR8 proteins from cells and were compared to control siRNA treated cells.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MTAB-898 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mRNAs regulated by Ars2 and DGCR8
siRNAs were used to deplete either Ars2 or DGCR8 proteins from cells and were compared to control siRNA treated cells.
ORGANISM(S): Homo sapiens 
2012-02-01 | E-MTAB-899 | biostudies-arrayexpress
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