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MetabolomicsIntestinal accumulation of microbiota-produced succinate caused by loss of microRNAs leads to diarrhea in weanling piglets
Diarrheal disease is a common health problem with complex causality. Although diarrhea is accompanied by disturbances in microbial diversity, how gut microbes are involved in the occurrence of diarrhea remains largely unknown. Here, using a pig model of post-weaning stress-induced diarrhea, we aim t...
2023-01-09 | MTBLS4040 | MetaboLights
ProteomicsComprehensive Metabolomic Profiling of Osteoarthritis Unraveling Sexually Dimorphic Patterns
Osteoarthritis (OA) is a chronic disease characterized by high morbidity, affecting multiple body systems and associated with systemic metabolic disorders. The clinical features of OA exhibit significant sexual dimorphism. However, the specific metabolic characteristics underlying this difference re...
ORGANISM(S): Human 
2024-12-11 | MSV000096636 | MassIVE
ProteomicsProteomic Profiling of the 5‑HT2B Receptor Agonist BW723C86 on Migration and Signaling in Mouse Bone Marrow‑Derived Macrophages
Mouse Bone marrow-derived macrophages (BMDMs) and HT22 neuronal cells (subjected to 2-hour oxygen-glucose deprivation, OGD-2h) were used in this study. To investigate cell migration, a Transwell assay was performed. For pharmacological intervention, cells were treated with either the serotonin recep...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-04 | PXD074138 | Pride
Mouse bone marrow‑derived macrophages (bmdms)，5‑ht2b receptor，bw723c86，transwell assay，lc-msms 
MetabolomicsIn plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids (Imaging MS assays)

Tapping into the metabolic cross-talk between a host and its virus can reveal unique strategies employed during infection. Viral infection is a dynamic process that generates an evolving metabolic landscape. Gaining a continuous view into the infection process is highly challenging and is limited...

2018-11-29 | MTBLS769 | MetaboLights
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