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TranscriptomicsNuclear factor kappa B activation-induced anti-apoptosis renders HER2 positive cells drug resistant and accelerates tumor growth
Breast cancers with HER2 overexpression are sensitive to drugs targeting the receptor or its kinase activity. HER2-targeting drugs are initially effective against HER2- positive breast cancer, but resistance inevitably occurs. We previously found that nuclear factor kappa B is hyper-activated in the...
ORGANISM(S): Homo sapiens 
2014-02-13 | E-GEOD-52707 | biostudies-arrayexpress
ProteomicsIntegrated Analysis of Global Proteome and Phosphoproteome in Cisplatin Resistant Bladder Cancer Cell Revealed the Molecular Signature Predictive to Patient Survival
Cisplatin-based chemotherapy is the standard care regimen in bladder cancer (BC). However, resistance to the therapy whose molecular mechanisms of the resistance are not fully elucidated rapidly develops in BC patients. Here we introduced multidimensional proteomic analysis providing different level...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD005308 | Pride
Phosphoproteomics Bladder cancer Cisplatin resistance Biological network Molecular signature 
UnknownSingle-Agent Mosunetuzumab Shows Durable Complete Responses in Patients With Relapsed or Refractory B-Cell Lymphomas: Phase I Dose-Escalation Study.
Not available
S-EPMC8824395 | biostudies-literature
UnknownMosunetuzumab monotherapy is active and tolerable in patients with relapsed/refractory diffuse large B-cell lymphoma.
Not available
S-EPMC10463194 | biostudies-literature
UnknownKnockdown of TRPM7 prevents tumor growth, migration, and invasion through the Src, Akt, and JNK pathway in bladder cancer.
Not available
S-EPMC7488071 | biostudies-literature
UnknownOccupational Exposure to Diesel Particulate Matter in Municipal Household Waste Workers.
Not available
S-EPMC4527826 | biostudies-literature
ProteomicsProteogenomic Integration Reveals Therapeutic Targets in Breast Cancer Xenografts
Huang K, Li S, Mertins P, Cao S, Gunawardena HP, Ruggles KV, et al., (2017) Nature Communications | 8:14864 | DOI: 10.1038/ncomms14864 | http://www.nature.com/articles/ncomms14864

Recent advances in mass spectrometry (MS) hav...

ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2019-08-28 | MSV000084249 | MassIVE
TranscriptomicsPrognostic signature of epithelial-mesenchymal transition in breast cancer
Epithelial-mesenchymal transition (EMT), a switch of polarized epithelial cells to a migratory, fibroblastoid phenotype, is considered a key process driving tumor cell invasiveness and metastasis. Using breast cancer cell lines as a model system, we sought to discover gene-expression signatures of ...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-13915 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human MCF7 breast cancer cell line treated with dioxin and DMSO control
MCF7 cells were treated with DMSO or 100 nM Dioxin for 16 hr. Gene expression changes were quantified by microarray analyses. Experiment Overall Design: HU133A and B arrays were used to quantify differences in RNA after treatment with 100 nM dioxin for 16 h. The experiment was repeated 3 times.
ORGANISM(S): Homo sapiens 
2007-10-31 | E-GEOD-7765 | biostudies-arrayexpress
UnknownA Multi-Center, Double-Blind Randomized Controlled Phase III Clinical Trial to Evaluate the Antiviral Activity and Safety of DA-2802 (Tenofovir Disoproxil Orotate) and Viread (Tenofovir Disoproxil Fumarate) in Chronic Hepatitis B Patients.
Not available
S-EPMC8938614 | biostudies-literature
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